Publications by authors named "Shiqing Guo"
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common condition linked to serious liver issues, with high serum levels of palmitic acid (PA) but unclear connections between PA and MASLD development.
- The study utilized advanced methods like gene expression analysis and animal models to investigate the role of the protein Porcupine in MASLD, finding that PA induces Porcupine production leading to inflammation and altered lipid metabolism.
- Results indicate that targeting Porcupine with an inhibitor called Wnt974 can reduce lipid buildup and inflammation in the liver, suggesting Porcupine as a potential therapeutic target for MASLD.
Protein kinase C (PKC) constitutes the main signal transduction pathway, and participates in the signal pathway of cell proliferation and movement in mammals. In this study, PKC-ɑ was obtained from Epinephelus coioides, an important marine fish cultivated in the coastal areas of southern China and Southeast Asia. The full length cDNA of PKC-ɑ was 3362 bp in length containing a 23 bp 5'UTR, a 1719 bp 3'UTR, and a 1620 bp open reading frame encoding 539 amino acids.
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