Publications by authors named "Shiqin Yang"

Article Synopsis
  • The study explores the genetic connections between Hunner interstitial cystitis (HIC) and autoimmune diseases (ADs), suggesting they may share common genetic factors.
  • Utilizing a large East Asian population, the researchers employed advanced statistical methods like Mendelian randomization to assess causal relationships and identify genetic markers linked to both conditions.
  • Results showed causal effects of certain autoimmune conditions on HIC and vice versa, along with insights into genetic variants affecting gene expression in autoimmune-related tissues, highlighting a potential shared genetic basis for these diseases.
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  • Obesity is a key factor in the progression of non-alcoholic fatty liver disease (NAFLD), but an effective non-invasive method to monitor its progression is currently unavailable.
  • A study analyzed the relationship between CT-based body composition measurements and NAFLD progression, utilizing liver biopsies and evaluating patients' NAFLD activity scores (NAS).
  • Results revealed that various body composition indicators, especially visceral fat index (VFI) and skeletal muscle indexes, are significantly related to NAFLD severity, highlighting the importance of monitoring these factors in obese patients.
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Background: Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. This study investigated the role of DPY30 in the development and progression of CRC cells, especially in the area of cellular glycolysis.

Methods: HT29 control cells and DPY30 knockdown cells were collected for tandem mass tag (TMT) labeling quantitative proteomics analysis of cellular total proteins (n=3).

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Article Synopsis
  • - The study investigates the mechanisms behind Hunner-type interstitial cystitis (HIC), focusing on urothelial damage and barrier dysfunction, and emphasizes the need for better understanding specific cell types and molecular targets to improve treatment effectiveness.
  • - Using single-cell RNA sequencing, researchers identified eight types of urothelial cells in HIC bladders and found significant loss of UPK3A umbrella cells and increased progenitor-like cells, which struggle to differentiate properly.
  • - The research highlights the TLR3-NR2F6 signaling pathways as key targets for therapeutic interventions, aiming to repair the urothelial barrier and improve bladder function in HIC patients, supported by both lab experiments and real-life testing.
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Purpose: To design a quick checklist for urodynamic study (UDS), aiming to reduce the occurrence of errors in the process, which may help to increase the quality of UDS. And further to analyze the effectiveness of this quick checklist for UDS quality control.

Methods: First, a quick checklist for uroflow study and pressure-flow study was developed, based on the International Continence Society-Good Urodynamic Practice standards, our previous studies, and recent literature, as well as expert suggestions.

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Introduction: This prospective study aimed to assess the effectiveness of a Y-shape connection device in reducing pain and bleeding in pediatric patients with indwelling catheters during urodynamic studies (UDS), while also obtaining effective results in the filling phase.

Methods: A total of 45 pediatric patients with a mean age of 13 years were included, all of whom underwent both a UDS with the Y-shape connection device (Method A) and a standard UDS procedure (Method B).

Results: The Y-shape connection device demonstrated similar overall urodynamic parameters compared to the standard procedure, while also resulting in significantly less bleeding ( = 0.

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Interstitial cystitis/bladder pain syndrome (IC/BPS) is a long-lasting and incapacitating disease, and the exact factors that affect its onset and advancement are still uncertain. Thus, the main aim was to explore new biomarkers and possible therapeutic targets for IC/BPS. Next-generation high-throughput sequencing experiments were performed on bladder tissues.

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Article Synopsis
  • * A systematic literature review was conducted that included 37 trials with over 5700 patients. It found no significant difference in the objective success rates of the surgeries, but PVS showed higher subjective success rates.
  • * The findings suggest that for synthetic sling options, TVT-RP and TVT-O are preferred, while PVS is the best choice for nonsynthetic slings due to its effectiveness and safety profile.
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Background: YouTube is commonly used by doctors to learn surgery. To date, no studies have evaluated the quality of videos on photoselective vaporization of the prostate (PVP) for benign prostatic hyperplasia (BPH) on YouTube. Our aim was to assess the educational value of YouTube videos regarding PVP.

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  • - An indigenous fungal strain, identified as Aspergillus niger, was isolated from lead-contaminated soil and demonstrated a remarkable ability to adsorb and accumulate lead ions (Pb(II)) effectively.
  • - Living A. niger removed 96.21%-100% of Pb(II) at varying concentrations, while modified versions of the fungus showed different adsorption percentages, highlighting the impact of treatment on lead absorption efficiency.
  • - The study employed scanning and transmission electron microscopy to visualize lead distribution inside and outside the fungal cells and developed kinetic models to analyze the adsorption process of modified fungal biomass.
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Background: Drought is a major abiotic stress factor that influences the yield of crops. Basic leucine zipper motif (bZIP) transcription factors play an important regulatory role in plant drought stress responses. However, the functions of a number of bZIP transcription factors in rice are still unknown.

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In this work, we studied the natural bioaccumulation and biosorption of Pb(II) in several common edible macrofungi. The macrofungi include the following species: Lentinus edodes, Pleurotus eryngii, Flammulina velutipes, Hypsizygus marmoreus, and Agrocybe cylindracea. The present analysis of Pb(II) revealed distinct capabilities of metal accumulation among individual species.

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This study aims to investigate the characteristics of genomic variation of pandemic A/H1N1/2009 influenza virus isolated in Fujian Province, China. Complete genome sequence analysis was performed on 14 strains of pandemic A/H1N1/2009 influenza virus isolated from Fujian during 2009-2012. All virus strains were typical low-pathogenic influenza viruses, with resistance to amantadine and sensitivity to neuraminidase inhibitors.

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The vibration characteristics of an aluminum surface subjected to ultrasonic waves were investigated with a combination of numerical simulation and experimental testing. The wetting behavior of solder droplets on the vibrating aluminum surface was also examined. The results show that the vibration pattern of the aluminum surface is inhomogeneous.

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Intestinal epithelial cells can respond to certain bacteria by producing an array of cytokines and chemokines which are associated with host immune responses. Lactobacillus acidophilus NCFM is a characterized probiotic, originally isolated from human feces. This study aimed to test the ability of L.

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Objective: To study the expression of immunity and inflammatory mediator factor PTX3 in intestinal epithelial cells treated with Lactobacillus acidophilus NCFM and further to reveal the regulatory mechanism.

Methods: Caco-2 cells were cocultured with Lactobacillus acidophilus NCFM for 0, 2, 4, 8, 12 h and 0, 0.5, 1, 2, 4 h respectively, then the total RNA and protein were extracted.

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A novel high voltage (HV) modulator that offers a short fall time to minimize sputtering effects and allow more precise control of the incident ion fluence in plasma immersion ion implantation is described. The use of 36 insulated-gate bipolar transistors in the 30 kV hard-tube pulser reduces the HV fall time to 3.5 μs, compared to a fall time of 80 μs if a pull-down resister is used.

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A novel plasma immersion ion implantation technique based on high power pulsed magnetron sputtering (HPPMS) discharge that can produce a high density metal plasma is described. The metal plasma is clean and does not suffer from contamination from macroparticles, and the process can be readily scaled up for industrial production. The hardware, working principle, and operation modes are described.

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A hybrid radio-frequency (rf)/direct-current (dc) system has been developed to control the biasing effects during deposition of diamondlike carbon (DLC) films onto the inner wall of polyethylene terephthalate (PET) bottles. An additional dc bias is coupled to the rf electrode to produce the effect of equivalent rf self-biasing. This allows more flexible control of the deposition of the DLC films which are intended to improve the gas barrier characteristics.

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A subsonic thermal spraying technique (STS) was used to make different biocomposite coatings on titanium alloys for preparing three kinds of implants: 8Ti2G, HA and 8H2B, respectively. The implants were embedded in a region of jaw of dogs whose teeth were pulled out three months previously. The dogs, in two groups, were killed 30 days and 90 days, respectively, after they were operated on.

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A novel power supply system that directly couples pulsed high voltage (HV) pulses and pulsed 13.56 MHz radio frequency (rf) has been developed for plasma processes. In this system, the sample holder is connected to both the rf generator and HV modulator.

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We studied the genetic and epidemic characteristics of influenza A (H3N2) viruses circulated in human in Fujian Province, south of China from 1996 to 2004. Phylogenetic analysis was carried out for genes encoding hemagglutinin1 (HA1) of influenza A virus (14 new and 11 previously reported reference sequences). Our studies revealed that in the 8 flu seasons, the mutations of HA1 genes occurred from time to time, which were responsible for about four times of antigenic drift of influenza H3N2 viruses in Fujian, China.

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A radio frequency (rf) inductively coupled plasma apparatus has been developed to simulate the atomic oxygen environment encountered in low Earth orbit (LEO). Basing on the novel design, the apparatus can achieve stable, long lasting operation, pure and high density oxygen plasma beam. Furthermore, the effective atomic oxygen flux can be regulated.

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