TRPM2-AS promotes ovarian cancer cell proliferation and inhibits cell apoptosis by upregulating the nearby gene TRPM2 via miR-6764-5p.

Ovarian cancer (OC) becomes a fatal gynecologic malignant cancer in females worldwide. Target therapy is a promising therapeutical choice for patients with OC, and identifying biomarkers and exploring molecular mechanisms are necessary. In this study, the functions and mechanism of long noncoding RNA transient receptor potential cation channel subfamily M member 2 antisense RNA (TRPM2-AS) in OC were explored.

Analysis of Clinical Efficacy of Laparoendoscopic Single-Site Surgery for Uterine Fibroids.

In order to determine the clinical efficacy of laparoendoscopic single-site surgery (LESS) for uterine fibroids (UFs), the study population comprises 65 patients who underwent hysteromyoma enucleation in our hospital from January 2020 to September 2021. Among them, 30 patients with conventional multiport laparoscopic myomectomy (MLS-M) are taken as the control group (CG), and the rest 35 patients with laparoendoscopic single-site myomectomy (LESS-M) are taken as the research group (RG). Perioperative indicators and incidence of complications are compared between groups.

CuO nanoparticles anchored on 3D bifunctional CNTs/copper foam cathode for electrocatalytic degradation of sulfamethoxazole over a broad pH range.

In this paper, nanoscale CuO particles was successfully anchored at defect sites of carbon nanotubes (CNTs), which doped on three-dimensional copper foam (CF) electrode (CuO@CNTs/CF). The compound as cathode was synthesized via dip-coating and rapid electrodeposition followed by annealing procedure, and conducted in heterogeneous electro-Fenton (EF) system. The CuO@CNTs/CF composites electrode enabled activate O to generate HO in situ and further Cu/CuO synergistic catalysis to produce reactive oxygen species for a broad pH-range via the heterogeneous EF process.

Pregabalin does not decrease acute pain or postoperative nausea and vomiting after hysterectomy: a meta-analysis.

Objective: Hysterectomy is associated with severe postoperative pain. The relative efficacy of pregabalin compared with other treatments for post-hysterectomy pain is unclear.

Methods: We searched the PubMed, Cochrane Library, and Web of Science databases for studies that compared the use of pregabalin and placebo for reducing pain in patients undergoing hysterectomy.

Sirtuin-7 knockdown inhibits the growth of endometrial cancer cells by inducing apoptosis via the NF-κB signaling pathway.

Sirtuin-7 is an evolutionarily conserved NAD-dependent deacetylase, which serves an important role in carcinogenesis. However, the potential mechanism of sirtuin-7 in endometrial cancer has not yet been investigated. The purpose of the present study was to investigate whether sirtuin-7 exhibits inhibitory effects on endometrial cancer cells.