Supernatural Beliefs-Based Intervention to Improve Type-2 Diabetes Self-Management: A Pilot Randomized Controlled Trial from China.

China has over 100 million people living with type 2 diabetes mellitus (T2DM). Interventions framed around pre-existing personal beliefs in the supernatural may improve T2DM self-management, but such interventions are lacking in China. This pilot randomized controlled trial (RCT) assessed the feasibility of a full-scale RCT to evaluate the efficacy of a supernatural beliefs-based intervention on T2DM management self-efficacy in China.

Pelvic bone tumor segmentation fusion algorithm based on fully convolutional neural network and conditional random field.

Background And Objective: Pelvic bone tumors represent a harmful orthopedic condition, encompassing both benign and malignant forms. Addressing the issue of limited accuracy in current machine learning algorithms for bone tumor image segmentation, we have developed an enhanced bone tumor image segmentation algorithm. This algorithm is built upon an improved full convolutional neural network, incorporating both the fully convolutional neural network (FCNN-4s) and a conditional random field (CRF) to achieve more precise segmentation.

Ablation of histone methyltransferase Suv39h2 in hepatocytes attenuates NASH in mice.

Aims: Non-alcoholic steatohepatitis (NASH) is characterized by aberrant lipid metabolism in hepatocytes. We investigated the involvement of a histone H3K9 methyltransferase Suv39h2 in the pathogenesis of NASH.

Methods And Materials: NASH is induced by feeding the mice with a high-fat high-carbohydrate (HFHC) diet or a high-fat choline-deficient amino acid defined (HFD-CDAA) diet.

Synovia tissue-specific exosomes participate in the dual variation of the osteoarthritis microenvironment via miR-182.

Osteoarthritis (OA) is the most common type of joint disease and the leading cause of chronic disability among older adults. As an important component of the joint, synovium influences the inflammatory and degenerative process of OA. This study found that miRNA 182 (miR-182) in synovium-specific exosomes can modulate inflammation and apoptotic signaling.

Activation of HDAC8 Can Suppress the Proliferation of Osteosarcoma Cells via and STAT3/ERK Signaling Pathways.

Objective: Osteosarcoma is the most common malignant bone cancer and is typically associated with poor prognosis. Histone deacetylase 8 (HDAC8) presents as an effective target in anti-tumor treatment in various tumors. As the functions of HDAC8 in osteosarcoma have not been studied thoroughly, our study aims to explore the effects of HDAC8 in osteosarcoma proliferation.

Characteristics and formation mechanism of Land use conflicts in northern Anhui: A Case study of Funan county.

The rapid development of global urbanization and industrialization not only promotes a significant improvement in the level of socio-economic development, but also exacerbates the complexity and vulnerability of regional land resource utilization, resulting in frequent land use conflicts and seriously constraining the sustainable development of regional socio-economic and ecological environment. Taking Funan County as an example, based on interpretation data of Landsat TM/ETM remote sensing image data from 1980 to 2020, this paper analyses the temporal and spatial evolution characteristics of land use conflict in Funan County from 1980 to 2020 using the ArcGIS spatial analysis method, land use conflict measurement model, geographically weighted regression and geographical detector and then deeply analyses the main factors affecting land use conflict in Funan County and its driving mechanisms. In descending order, land use types undergoing the most change include cultivated land, urban and rural construction land, grassland, forestland and water area.

Dehydrocostus lactone (DHC) promotes osteoblastic differentiation and mineralization through p38/RUNX-2 signaling.

Dysregulation of osteoblastic differentiation is an important risk factor of osteoporosis, the therapy of which is challenging. Dehydrocostus lactone (DHC), a sesquiterpene isolated from medicinal plants, has displayed anti-inflammatory and antitumor properties. In this study, we investigated the effects of DHC on osteoblastic differentiation and mineralization of MC3T3-E1 cells.

Bone tumor examination based on FCNN-4s and CRF fine segmentation fusion algorithm.

Background And Objective: Bone tumor is a kind of harmful orthopedic disease, there are benign and malignant points. Aiming at the problem that the accuracy of the existing machine learning algorithm for bone tumor image segmentation is not high, a bone tumor image segmentation algorithm based on improved full convolutional neural network which consists fully convolutional neural network (FCNN-4s) and conditional random field (CRF).

Methodology: The improved fully convolutional neural network (FCNN-4s) was used to perform coarse segmentation on preprocessed images.

Occurrence of microplastic pollution in rivers globally: Driving factors of distribution and ecological risk assessment.

Microplastics, as global emerging pollutants, have received significant attention worldwide due to their ubiquitous presence in the rivers. However, there is still a lack of clarity on the occurrence, driving factors, and ecological risks of microplastics in rivers worldwide. In this study, a global microplastic dataset based on 862 water samples and 445 sediment samples obtained from 63 articles was constructed, which revealed the temporal and spatial distribution of abundance and morphological characteristics of microplastics in rivers across the globe.

A Comparison of the Safety, Efficacy, and Accuracy of Frame-Based versus Remebot Robot-Assisted Stereotactic Systems for Biopsy of Brainstem Tumors.

Background: Brainstem tumors are rare and extremely heterogeneous and present significant challenges in surgical treatment. Thus, biopsies often set the foundation for the diagnosis of brainstem tumors. Multimodal, image-guided, robot-assisted frameless stereotactic biopsies are increasingly popular in neurosurgery centers.

Geographical pattern of minerals and its association with health disparities in the USA.

This study aimed to determine the common latent patterns of geographical distribution of health-related minerals across the USA and to evaluate the real-world cumulative effects of these patterns on overall population health. It was an ecological study using county-level data (3080 contiguous counties) on the concentrations of 14 minerals (i.e.

ECSS: High-Embedding-Capacity Audio Watermarking with Diversity Reception.

Digital audio watermarking is a promising technology for copyright protection, yet its low embedding capacity remains a challenge for widespread applications. In this paper, the spread-spectrum watermarking algorithm is viewed as a communication channel, and the embedding capacity is analyzed and modeled with information theory. Following this embedding capacity model, we propose the extended-codebook spread-spectrum (ECSS) watermarking algorithm to heighten the embedding capacity.

Recent advances in cell-based and cell-free therapeutic approaches for sarcopenia.

Sarcopenia is a progressive loss of muscle mass and function that is connected with increased hospital expenditures, falls, fractures, and mortality. Although muscle loss has been related to aging, injury, hormonal imbalances, and diseases such as malignancies, chronic obstructive pulmonary disease, heart failure, and kidney failure, the underlying pathogenic mechanisms of sarcopenia are unclear. Exercise-based interventions and multimodal strategies are currently being considered as potential therapeutic approaches to prevent or treat these diseases.

The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma.

Standard chemotherapy of Glioblastoma multiforme (GBM) using temozolomide (TMZ) frequently fails due to acquired chemoresistance. Tumor-associated macrophages and microglia (TAMs) as major immune cell population in the tumor microenvironment are potential modulators of TMZ response. However; little is known about how TAMs participate in TMZ induced chemoresistance.

Femoral image segmentation based on two-stage convolutional network using 3D-DMFNet and 3D-ResUnet.

Objective: The femur is a typical human long bone with an irregular spatial structure. Femoral fractures are the most common occurrence in middle-aged and older adults. The structure of human bone tissue is very complex, and there are significant differences between individuals.

Pulses outweigh cumulative effects of water diversion from river to lake on lacustrine phytoplankton communities.

Due to the allochthonous input of nutrients and species, the cumulative effects of water diversion on water-receiving lakes deserve attention. Taking the water diversion project from the Yangtze River to Lake Taihu (WDYT) as an example, we explored the temporal effects of WDYT on the phytoplankton community and physicochemical habitat of Lake Taihu in autumn and winter from 2013 to 2018. Although the short-term diversion significantly increased the risk of importing nutrients, the relatively high quality of the diversion water compared with other inflow rivers had improved the water quality of the water-receiving lake region.

Large scale application of pulse oximeter and auscultation in screening of neonatal congenital heart disease.

Purpose: To conduct a retrospective evaluation of a large clinical implementation of combined pulse oximeter (POX) and cardiac auscultation as a fast-screening device for congenital heart disease (CHD).

Methods: Every newborn in a large maternity healthcare center received auscultation and POX screening within 24 hours after delivery. When an abnormal heart murmur or SpO level was detected, an echocardiogram was ordered to confirm the diagnosis of CHD.

Long non-coding RNA plasmacytoma variant translocation 1 and growth arrest specific 5 regulate each other in osteoarthritis to regulate the apoptosis of chondrocytes.

Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) and growth arrest specific 5 (GAS5) have opposite functions in the apoptosis of chondrocytes, which are involved in the pathogenesis of osteoarthritis (OA). The opposite roles of PVT1 and GAS5 in OA may indicate the existence of crosstalk between them in OA. This study aimed to explore the possible interaction between PVT1 and GAS5 in OA.

MicroRNA-455-3p regulates proliferation and osteoclast differentiation of RAW264.7 cells by targeting PTEN.

Background: Macrophages are one of the important cells in immune system. In this article, we aim to explore the regulatory role of miR-455-3p on proliferation and osteoblast differentiation of RAW264.7 cells.

Health Effects of Religion, Spirituality, and Supernatural Beliefs in Mainland China: A Systematic Review.

Effects of religion, spirituality and supernatural beliefs (RSS) upon health in mainland China remain poorly understood, despite strong RSS beliefs influencing Chinese society. We conducted a Chinese-English bilingual systematic review to summarize the state of RSS-health research in mainland China. Study quality was assessed using the Critical Appraisal Skills Program tool.

Effect of Robot-Assisted Neuroendoscopic Hematoma Evacuation Combined Intracranial Pressure Monitoring for the Treatment of Hypertensive Intracerebral Hemorrhage.

This study aimed to investigate the clinical efficacy of robot-assisted neuroendoscopic hematoma evacuation combined intracranial pressure (ICP) monitoring for the treatment of hypertensive intracerebral hemorrhage (HICH). A retrospective analysis of 53 patients with HICH undergoing neuroendoscopic hematoma evacuation in our department from January 2016 to December 2020 was performed. We divided the patients into two groups: the neuroendoscopic group ( = 32) and the robot-assisted neuroendoscopic combined ICP monitoring group ( = 21).

Would COVID-19 vaccination willingness increase if mobile technologies prohibit unvaccinated individuals from public spaces? A nationwide discrete choice experiment from China.

Background: Achieving COVID-19 community protection (aka, herd immunity) in China may be challenging because many individuals remain unsure or are unwilling to be vaccinated. One potential means to increase COVID-19 vaccine uptake is to essentially mandate vaccination by using existing mobile technologies that can prohibit unvaccinated individuals from certain public spaces. The "Health Code" is a ubiquitous mobile phone app in China that regulates freedom of travel based on individuals' predicted risk of exposure to SARS-CoV-2.

The role of surgical resection in primary central nervous system lymphoma: a single-center retrospective analysis of 70 patients.

Background: The aim of this study was to evaluate the effect of surgical resection and stereotactic biopsy on the complication rate, progression-free survival (PFS) and overall survival (OS) of 70 patients diagnosed at a single institution with primary central nervous system lymphoma (PCNSL) and to explore the predictors of selection for resection and the prognostic factors of PCNSL.

Methods: A retrospective analysis was performed of 70 patients with PCNSL that was diagnosed by surgical resection or stereotactic brain biopsy in our department from January 2013 to May 2019. We divided the patients into two groups: a resection group (n = 28) and a stereotactic biopsy group (n = 42).