TP63 transcriptionally regulates SLC7A5 to suppress ferroptosis in head and neck squamous cell carcinoma.

Background: Most head and neck squamous cell carcinoma (HNSCC) patients are diagnosed at an advanced local stage. While immunotherapy has improved survival rates, only a minority of patients respond durably to targeted immunotherapies, posing substantial clinical challenges. We investigated the heterogeneity of the tumor microenvironment in HNSCC cohorts before and after immunotherapy by analyzing single-cell RNA sequencing (scRNA-seq) data and bulk RNA sequencing datasets retrieved from public databases.

Implications of mC modifications in ribosomal proteins on oxidative stress, metabolic reprogramming, and immune responses in patients with mid-to-late-stage head and neck squamous cell carcinoma: Insights from nanopore sequencing.

Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is a malignancy characterized by a high incidence and recurrence rate. 5-methylcytosine (mC) RNA modification is a common alteration affecting cancer progression; however, how mC operates within the tumor microenvironment of HNSCC remains to be elucidated.

Methods: We conducted Nanopore sequencing on 3 pairs of cancer and paracancerous tissues from mid- and late-stage HNSCC, obtaining 132 upregulated genes (transcriptomically upregulated, mC elevated) and 129 downregulated genes (transcriptomically downregulated, mC reduced).

Well-defined NiN nanoparticles armored in hollow carbon nanotube shell for high-efficiency bifunctional hydrogen electrocatalysis.

Alkaline H-O fuel cells and water electrolysis are crucial for hydrogen energy recycling. However, the sluggish kinetics of the hydrogen oxidation reaction (HOR) and hydrogen evolution reaction (HER) in an alkaline medium pose significant obstacles. Thus, it is imperative but challenging to develop highly efficient and stable non-precious metal electrocatalysts for alkaline HOR and HER.

Adoption of Dexmedetomidine in Different Doses at Different Timing in Perioperative Patients.

Unlabelled: Dexmedetomidine (Dex) is an alpha-2 agonist used for sedation during various procedures. Dex activates 2-adrenoceptors, and causes the decrease of sympathetic tone, with attenuation of the neuroendocrine and hemodynamic responses to anesthesia and surgery; it reduces anesthetic and opioid requirements; and causes sedation and analgesia.

Objective: it was to compare the perioperative effects of different doses of Dex at different timing in patients using Dex during the perioperative period adopting a medical data classification algorithm based on optimized semi-supervised collaborative training (Tri-training).

Existence of traveling wave solutions for a delayed nonlocal dispersal SIR epidemic model with the critical wave speed.

This paper is about the existence of traveling wave solutions for a delayed nonlocal dispersal SIR epidemic model with the critical wave speed. Because of the introduction of nonlocal dispersal and the generality of incidence function, it is difficult to investigate the existence of critical traveling waves. To this end, we construct an auxiliary system and show the existence of traveling waves for the auxiliary system.

Shape-Defined Hollow Structural Co-MOF-74 and Metal Nanoparticles@Co-MOF-74 Composite through a Transformation Strategy for Enhanced Photocatalysis Performance.

In recent years, metal-organic frameworks (MOFs) have received extensive interest because of the diversity of their composition, structure, and function. To promote the MOFs' function and performance, the construction of hollow structural metal-organic frameworks and nanoparticle-MOF composites is significantly effective but remains a considerable challenge. In this article, a transformation strategy is developed to synthesize hollow structural Co-MOF-74 by solvothermal transformation of ZIF-67.