Publications by authors named "Shiqian Pu"
Identification of diagnostic candidate genes in COVID-19 patients with sepsis.
Immun Inflamm Dis
October 2024
Article Synopsis
- Scientists are studying how COVID-19 and sepsis are related, trying to find genes that help diagnose COVID-19 patients with sepsis.
- They used special tools and methods to analyze gene data and found 13 important genes that can help diagnose this condition.
- Five key genes were identified that are linked to the immune system, which could help doctors better understand and treat COVID-19 patients who also have sepsis.
Methods: Gene expression profiles of GSE13904, GSE26378, GSE26440, GSE65682, and GSE69528 were obtained from the National Center for Biotechnology Information (NCBI). The differentially expressed genes (DEGs) were searched using limma software package. Gene Ontology (GO) functional analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and protein-protein interaction (PPI) network analysis were performed to elucidate molecular mechanisms of DEGs and screen hub genes.
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