Advances and prospects on production of lactulose and epilactose by cellobiose 2-epimerases: A review.

Lactulose and epilactose are nondigestible disaccharides with a wide range of applications in clinical medicine, nutrition, and the food industry due to their health-benefiting properties. Their chemical synthesis typically involves stringent catalytic conditions and intricate reaction procedures, resulting in elevated production costs and challenges in product separation. Cellobiose 2-epimerases (CEs) facilitate the isomerization and epimerization of lactose to produce lactulose and epilactose directly, without the need for co-substrates.