A caged luciferin analogue generating near-infrared bioluminescence for activity-sensing of labile iron.

Iron plays a vital role in physiological processes due to its high oxygen affinity and efficient redox capability. However, perturbations in iron homeostasis, particularly in its labile forms that drive oxidative stress, have been implicated in a spectrum of pathologies, including infectious diseases, malignancies, and neurodegenerative disorders. Despite the critical importance of detecting labile Fe, conventional fluorescent and bioluminescent probes are constrained by inherent limitations, such as suboptimal sensitivity, elevated background noise, and inadequate tissue penetration depth.

GABA transporter 1 is a promising drug target for CUL4B mutation-associated epilepsy.

Cullin 4B (CUL4B) is the scaffold protein in the CUL4B-RING E3 ubiquitin ligase (CRL4B) complex. Loss-of-function mutations in the human CUL4B gene result in syndromic X-linked intellectual disability (XLID). In addition to intellectual disability, patients with CUL4B mutations exhibit epilepsy.

Radical-triggered ring-opening of aminocyclopropane for detection of hydroxyl radicals in living cells.

Hydroxyl radicals (˙OH), highly reactive oxygen species involved in oxidative stress and cancer therapy, are challenging to detect intracellularly due to their short lifetime, low concentration, and high reactivity. To address this, a novel ˙OH-specific fluorescent probe, CC-7, was developed by integrating an aminocyclopropane group into a coumarin derivative. This design was inspired by the radical-mediated ring-opening of aminocyclopropanes in synthetic chemistry.

Systemic immune-inflammation index and long-term mortality in patients with hypertension: a cohort study.

Objective: The objective of this study was to examine the relationship between systemic inflammation and long-term mortality in patients with hypertension.

Methods: The study employed a retrospective cohort design. The study population was derived from the National Health and Nutrition Examination Survey (NHANES), and the mortality data for this population was acquired from the National Death Index (NDI) database.

X-ray induced in-situ ferroptosis through the Fenton reaction of iron supplements for the cancer therapy.

The potential of iron-based therapeutic agents in enhancing radiotherapy efficacy through catalyzing the Fenton reaction has garnered widespread interest. The inherent instability of ferrous ions requires the use of complex ligands for the ligand-dependent reduction from Fe to Fe, thereby boosting ferroptosis through inducing the Fenton reaction. However, the reliance on complex redox systems and potential long-term toxicity have seriously limited the clinical application in cancer treatment.

Myocardial hypertrophy: the differentiation of uremic, hypertensive, and hypertrophic cardiomyopathies by cardiac MRI.

Objectives: To apply cardiac magnetic resonance imaging (CMR) for detailed myocardial characterization in uremic cardiomyopathy (UC), hypertensive cardiomyopathy (HTN), and hypertrophic cardiomyopathy (HCM) aiming to enrich the understanding of UC's etiology and further support the development of therapeutic strategies.

Methods: A total of 152 patients (age: 49.2 ± 9.

Quantification of subclinical plaque characteristics and perivascular fat using coronary computed tomography angiography (CCTA) among individuals with human immunodeficiency virus (HIV).

Background: People infected with human immunodeficiency virus (PIWH) have a higher risk of cardiovascular events. This study was designed to compare the differences in plaque characteristics and perivascular fat between subclinical coronary atherosclerosis in PIWH and healthy controls (HC) by coronary computed tomography angiography (CCTA). We also assessed the associations between human immunodeficiency virus (HIV) infection, antiretroviral therapy (ART), and coronary artery disease (CAD).

Coronary CTA-based radiomic signature of pericoronary adipose tissue predict rapid plaque progression.

Objectives: To explore the value of radiomic features derived from pericoronary adipose tissue (PCAT) obtained by coronary computed tomography angiography for prediction of coronary rapid plaque progression (RPP).

Methods: A total of 1233 patients from two centers were included in this multicenter retrospective study. The participants were divided into training, internal validation, and external validation cohorts.

Myocardial Injury in Peritoneal Dialysis Patients Assessed by Multiparametric MRI: Relationship With Left Ventricular Phenotypes.

Background: Myocardial injury is common in end-stage renal disease (ESRD) patients, but the presence and severity of myocardial injury in different left ventricular (LV) phenotypes were still not fully explored.

Purpose: To evaluate myocardial tissue characteristics and deformation in ESRD patients on peritoneal dialysis separated into normal geometry, concentric remodeling, concentric left ventricular hypertrophy (LVH) and eccentric LVH patterns by multiparametric cardiac MRI.

Study Type: Prospective.

CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ.

Dysregulated lineage commitment of mesenchymal stem cells (MSCs) contributes to impaired bone formation and an imbalance between adipogenesis and osteogenesis during skeletal aging and osteoporosis. The intrinsic cellular mechanism that regulates MSC commitment remains unclear. Here, we identified Cullin 4B (CUL4B) as a critical regulator of MSC commitment.

Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.

Diabetic kidney disease (DKD) is the most prevalent chronic kidney disease. Macrophage infiltration in the kidney is critical for the progression of DKD. However, the underlying mechanism is far from clear.

CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation.

CD4 T helper (Th) cell differentiation is regulated by lineage-specific expression of transcription factors, which is tightly associated with epigenetic modifications, including histone acetylation and methylation. However, the factors regulating histone modifications involved in Th cell differentiation remain largely unknown. We herein demonstrated a critical role of Cullin 4B (CUL4B) in restricting Th1 and Th2 cell differentiation.

Heart failure with preserved ejection fraction in post myocardial infarction patients: a myocardial magnetic resonance (MR) tissue tracking study.

Background: This study aimed to explore the value of cardiac magnetic resonance tissue tracking (CMR-TT) technology in evaluating heart failure with preserved ejection fraction (HFpEF) in patients with chronic myocardial infarction (CMI).

Methods: Between June 2016 and March 2022, we included a consecutive series of 92 patients with CMI and 40 healthy controls in this retrospective study. The CMI patients enrolled were divided into different subgroups [HFpEF-CMI group (n=54) and non- heart failure (HF)-CMI group (n=38)] according to the Heart Failure Association (HFA)-PEFF (step 1: P, pre-test assessment; step 2: E, echocardiography and natriuretic peptide score; step 3: F1, functional testing; step 4: F2, final aetiology) diagnostic algorithm.

Serial Cardiac MRI for Quantification of the Dynamics of Anthracycline-Induced Subclinical Myocardial Injury.

Background: Anthracyclines are known to be associated with chemotherapy-induced cardiotoxicity. Limited data focus on dynamic myocardial injury during the course of chemotherapy in patients with breast cancer.

Purpose: To investigate the variation of tissue characterization and myocardial deformation derived by cardiac MRI during anthracycline chemotherapy.

Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking Study.

Background: LA function has been recognized as a significant prognostic marker in many cardiovascular diseases. Cardiovascular magnetic resonance feature tracking (CMR-FT) represents a promising technique for left atrial function evaluation. The size and location of myocardial infarction are important factors in the cause of adverse left ventricular remodeling, but the effect on the left atriam is unclear.

Compound Mutations of the COL4A3 including a Novel Allele Identified in a Patient with Alport Syndrome.

Alport syndrome (AS) is a hereditary nephropathy which is characterized by molecular abnormalities in collagen IV. Here, we report compound mutations of the COL4A3 gene including a novel allele identified in a patient with Alport syndrome. The patient was a 25-year-old Chinese woman.

Quantification of plaque characteristics detected by dual source computed tomography angiography to predict myocardial ischemia as assessed by single photon emission computed tomography myocardial perfusion imaging.

Background: We aim to evaluate the relationship between quantitative plaque characteristics detected by dual-source computed tomography angiography (DSCTA) and myocardial ischemia as assessed by single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI).

Methods: In this study, 460 consecutive patients with suspected coronary artery disease (CAD) underwent DSCTA and stress/rest SPECT-MPI, and 179 patients with coronary artery plaques were quantitatively analyzed. Quantitative coronary artery plaque measurements including total plaque volume, the volume of non-calcified plaque, calcified plaque volume, low-density noncalcified plaque volume, total plaque burden, calcified plaque burden, non-calcified plaque burden, low-density non-calcified plaque (LDNCP) burden, remodeling index, plaque length, maximum diameter stenosis were provided by the automated software (Release 5.

lncRNA CADM1-AS1 inhibits cell-cycle progression and invasion via PTEN/AKT/GSK-3β axis in hepatocellular carcinoma.

CADM1-AS1 (cell adhesion molecule 1 antisense RNA 1, long non-coding RNA), was firstly characterized in renal clear cell carcinoma, and exhibits a tumor suppressor role. However, its clinical relevance and exact effects in hepatocellular carcinoma (HCC) remain unknown. Therefore, in this study, we aimed to assess the clinical significance and function of CADM1-AS1 in HCC.

Lung nodules assessment in ultra-low-dose CT with iterative reconstruction compared to conventional dose CT.

Background: To retrospectively assess whether the low-voltage lung CT scan coupled with iterative reconstruction algorithms can be an optimal scanning method for measuring the size and density of lung nodules in cancer patients.

Methods: Eighty two cancer patients receiving both chest scan with low-voltage (80 kV) and abdomen CT scan with standard voltage (120 kV) were enrolled in this study. Lung nodules were measured manually and semi-automatically by two different computer-aided diagnosis (CAD) systems.

Polybrominated diphenyl ethers in human hair from the college environment: comparison with indoor dust.

Eight Polybrominated diphenyl ether (PBDE) congeners (BDE 28, 47, 99, 100, 153, 154, 183 and 209) were determined to examine the hair burden at low concentrations, and the relationship between PBDE concentrations in human hair and indoor dust from a college environment (Shanghai University campus). Chemical analyses showed that the total concentrations of PBDEs in hair ranged from 4.04 to 99 ng/g dw, and were found to be fourfold higher in females than in males (p < 0.

Control of resonant weak-light solitons via a periodic modulated control field.

We investigate propagation and control of weak-light spatial solitons in a resonant three-level atomic system with a periodic modulated control field. It is shown that the periodic modulation acts like periodic potential which resists the propagation of the soliton in transverse direction. The soliton could be trapped by the periodic potential in the input channel.

Tunneling-induced large cross-phase modulation in an asymmetric quantum well.

We propose an asymmetric double AlGaAs/GaAs quantum well structure with a common continuum to generate a large cross-phase modulation (XPM). It is found, owing to resonant tunneling, that a large XPM can be achieved with vanishing linear and two-photon absorptions.