A select inhibitor of MORC2 encapsulated by chimeric membranecoated DNA nanocage target alleviation TNBC progression.

Triple-negative breast cancer (TNBC) is the most malignant type of breast cancer and lacks effective targeted therapeutic drugs, resulting in a high recurrence rate and worse outcome. In this study, bioinformatic analysis and a series of experiments demonstrated that MOCR2 was highly expressed in TNBC and closely associated with poor prognosis, indicating that MOCR2 may be a potential therapeutic target for TNBC. Subsequently, Angoline was identified as an inhibitor of MORC2 protein by high-throughput screening and can significantly kill the TNBC cells by blocking cell cycle and inducing apoptosis.

Elemene Hydrogel Modulates the Tumor Immune Microenvironment for Enhanced Treatment of Postoperative Cancer Recurrence and Metastases.

As a representative active ingredient of traditional Chinese medicine (TCM) and a clinically approved anticancer drug, elemene (ELE) exhibits exciting potential in the antitumor field; however, appropriate drug formulations still need to be explored for specific diseases such as postoperative cancer recurrence and metastasis. Herein, we report an ELE hydrogel with controlled drug release kinetics that can allow ELE to maintain effective concentrations at local lesion sites for extended periods to enhance the bioavailability of ELE. Concretely, dopamine-conjugated hyaluronic acid is synthesized and utilized to prepare ELE nanodrug-embedded hydrogels.

Unleashing the potential: integrating nano-delivery systems with traditional Chinese medicine.

This review explores the potential of integrating nano-delivery systems with traditional Chinese herbal medicine, acupuncture, and Chinese medical theory. It highlights the intersections and potential of nano-delivery systems in enhancing the effectiveness of traditional herbal medicine and acupuncture treatments. In addition, it discusses how the integration of nano-delivery systems with Chinese medical theory can modernize herbal medicine and make it more readily accessible on a global scale.

Preparation of modified reed carbon composite hydrogels for trapping Cu, Ni and methylene blue in aqueous solutions.

The pollution of heavy metal ions and organic dyes seriously endangers human health and causes acute environmental problems. The adsorption method is extensively adopted in the treatment of water pollution which is more harmful to human health. In this work, the original reed carbon (ORC) was functionalized by polyethyleneimine (PEI).

Chitosan-based composite microspheres for treatment of hexavalent chromium and EBBR from aqueous solution.

Hexavalent chromium is widely used in industrial fields, but its pollution has posed a great threat to the environment due to its high toxicity. We created a chitosan-based microsphere biosorbent (CP) by combining polyethyleneimine with chitosan adopting inverse emulsion polymerization method. Under the optimal conditions (pH = 3), the maximum adsorption capacity of composite microspheres can reach 299.

The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits.

The report of bradycardia caused by propofol is increasing. In the experiment, we investigated the chronotropic function of propofol and the underlying mechanism. Rabbits of both sexes were randomly divided into 4 groups: propofol 5 mg/kg group, 10 mg/kg group, 15 mg/kg group, and sham group.

Functionalized cotton charcoal/chitosan biomass-based hydrogel for capturing Pb, Cu and MB.

In this work, a porous multi-functional biomass carbon was prepared by acid-base modification method, which realized the reuse of waste cotton material. Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared. This not only increases the adsorption performance of the adsorbent but also improves the stability of hydrogel.

Factors associated with patients' decision on colorectal cancer screening.

Cancer prevention and control are critical public health concerns. However, the screening uptake and referral rate for colorectal cancer (CRC) in Taiwan remain low. This study focused on the factors influencing whether a patient with a CRC diagnosis chooses to undergo referral follow-up.

Effective removal of heavy metals from water using porous lignin-based adsorbents.

Multifunctional composite materials are the key to improving removal capacity and environmental utility. Here, the adsorbent (SLCA) was obtained by free-radical polymerization of acrylic acid with sodium lignosulfonate and citric acid. FTIR, SEM, TGA and XPS characterization methods were used to prove the structure and properties of SLCA adsorbents.

Synthesis of sodium lignosulfonate-guar gum composite hydrogel for the removal of Cu and Co.

As an emerging pollutant treatment material, hydrogel is known for its good adsorption capacity and environmental friendliness. In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure. The optimized synthesized product was applied to the removal of Cu and Co in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g of Cu, 601 mg g of Co, respectively.

Esmolol activates endogenous neurokinin activity inhibiting infarction-induced arrhythmias in rats: novel mechanisms of anti-arrhythmia.

Endogenous neurokinin and adrenergic mechanisms might co-participate in the pathology of acute myocardial infarction (MI). This study sought to investigate the role of endogenous neurokinin and its relationship with β1-adrenergic mechanism in the infarction induced arrhythmias. In 60min of MI in rats, the contents of substance P (SP), a native agonist of neurokinin 1 receptor (NK1-R), norepinephrine (NE), NK1-R and β1-adrenergic receptor in the myocardium at risk of ischemia were examined and the ventricular arrhythmias were analyzed.