Publications by authors named "Shiqi Gui"
Article Synopsis
- Aging is linked to changes in circadian rhythms and stem cell depletion, but the influence of circadian systems on skeletal aging is not fully understood.
- In male mice, reduced levels of the circadian protein BMAL1 in bone marrow endothelial cells were found to disrupt the balance of extracellular matrix proteins, leading to increased breakdown of fibrillin-1 (FBN1) which affects bone health.
- The loss of BMAL1 activates TGF-β signaling, promoting further breakdown of FBN1 and resulting in stem cell exhaustion and increased osteoclast activity, highlighting the role of endothelial cells in maintaining skeletal integrity during aging.
Background: Studies have shown the positive impact of perceived social support on cognitive function among older adults in rural areas. However, existing studies often overlook the impact of different support sources. This study aimed to explore the relationship between the diverse sources of perceived social support and cognitive function.
View Article and Find Full Text PDFBackground: While evidence supports cognitive reserve (CR) in preserving cognitive function, longitudinal validation of CR proxies, including later-life factors, remains scarce. This study aims to validate CR's stability over time and its relation to cognitive function in rural Chinese older adults.
Methods: Within the project on the health status of rural older adults (HSRO), the survey included baseline assessment (2019) and follow-up assessment (2022).
Background: The concept of cognitive reserve (CR) plays a crucial role in understanding cognitive aging and resilience. Accumulating evidence revealed the influence of CR proxy on cognitive function, but it remains unknown whether a reverse association or reciprocal effect exists.
Objective: The aim of this study is to observe the bidirectional relationship between cognitive reserve proxies and cognitive function among older adults in rural Chinese communities, providing a better understanding of the underlying mechanisms and potential moderating factors involved.