Publications by authors named "Shiqi Cai"
Article Synopsis
- - The study investigated carbapenem resistance in the carbapenem-resistant complex (CRECC) over ten years in a Zhejiang hospital, revealing an overall rise from 5.5% to 18.3% resistance rates.
- - Among the 82 detected CRECC isolates, NDM-1 was the most common carbapenemase, suggesting specific genetic factors contribute to resistance, along with overactive efflux pumps and disrupted outer membrane proteins.
- - The findings emphasize the urgent need for improved infection control measures in hospitals due to the increasing prevalence of carbapenem-resistant strains.
Article Synopsis
- Cisplatin induces acute kidney injury (AKI) through mitochondrial damage and apoptosis, necessitating effective treatments.
- The compound (+)-14,15-Dehydrovincamine, derived from Vincamine, has been found to significantly improve mitochondrial function and reduce apoptosis in renal tubular cells affected by cisplatin-induced AKI.
- The protective mechanism of (+)-14,15-Dehydrovincamine involves inhibiting the JNK/Mff/Drp1 pathway, which helps maintain mitochondrial stability and reduces cell death during AKI.
As a widely spread Gram-negative bacteria, Klebsiella pneumoniae (KP) mainly causes acquired infections in hospitals, such as lung infections, urinary tract infections, and bloodstream infections. In recent years, the number of multidrug-resistant KP strains has increased dramatically, posing a great threat to human health. Carbapenem-resistant KP (CRKP) can be colonized in human body, especially in gastrointestinal tract, and some colonized patients can be infected during hospitalization, among which invasive operation, underlying disease, admission to intensive care unit, antibiotic use, severity of the primary disease, advanced age, operation, coma, and renal failure are common risk factors for secondary infection.
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- The study explores the worsening threat of carbapenem-resistant Klebsiella pneumoniae (CRKP) in healthcare, focusing on the evolutionary pathways of pKPC-2-bearing plasmids, which are crucial for antibiotic resistance.
- Researchers collected 237 CRKP strains and performed advanced sequencing and bioinformatics analyses to categorize the plasmids into three subgroups based on their unique evolutionary events and resistance mechanisms.
- The findings highlight a high incidence of multicopy antibiotic resistance genes, which significantly affect treatment outcomes, especially in reducing sensitivity to ceftazidime/avibactam, ultimately underscoring the complex dynamics of resistance in hospital settings.
Background: Immunological disorder remains a great challenge in severe poly-trauma, in which lymphopenia is an important contributor. The purpose of present study is to explore whether ferroptosis, a new manner of programmed cell death (PCD), is involved in the lymphocyte depletion and predictive to the adverse prognosis of severe injuries.
Patients And Methods: Severe polytrauma patients admitted from January 2022 to December 2022 in our trauma center were prospectively investigated.
Here, our objective was to explore the molecular mechanism underlying ceftazidime-avibactam resistance in a novel CMY-178 variant produced by the clinical Escherichia coli strain AR13438. The antibiotic susceptibility of the clinical isolate, its transconjugants, and its transformants harboring transferable were determined by the agar dilution method. S1-PFGE, cloning experiments, and whole-genome sequencing (WGS) were performed to investigate the molecular characteristics of ceftazidime-avibactam resistance genes.
View Article and Find Full Text PDFDeveloping robust and sensitive food safety detection methods is important for human health. Electrochemiluminescence (ECL) is a powerful analytical technique for complete separation of input source (electricity) and output signal (light), thereby significantly reducing background ECL signal. ECL biosensors have attracted considerable attention owing to their high sensitivity and wide dynamic range in food safety detection.
View Article and Find Full Text PDFBackground: Myeloid-derived suppressor cells (MDSCs) and cyclooxy-genase-2 (COX-2)/Prostaglandin E2 (PGE2) axis are important contributors to sepsis-induced immune-suppression. The purpose of present study is to explore whether COX-2 inhibitor can improve immunological disorder after sepsis via regulating MDSCs.
Methods: A ''two-hit'' model reflecting clinical sepsis development was performed.
Objective: This study aims to assess the influence of tracheostomy timing on outcomes among trauma patients, including mortality, medical resource utility and incidence of pneumonia.
Method: A systematic review of the literature was conducted by internet search. Data were extracted from selected studies and analyzed using Stata to compare outcomes in trauma patients with early tracheostomy (ET) or late tracheostomy (LT)/prolonged intubation (PI).