Efficacy and safety of transscleral cyclophotocoagulation versus cyclocryotherapy in the treatment of intractable glaucoma: A systematic review and meta-analysis.

To perform a meta-analysis to compare the efficacy and safety of diode laser transscleral cyclophotocoagulation (TSCPC) and cyclocryotherapy (CCT) in the treatment of intractable glaucoma. Systemic searches of the Ovid MEDLINE, EMBASE, and Cochrane Library databases yielded experimental and observational comparative studies. TSCPC and CCT efficacy and safety outcomes were compared.

Bilateral optic disc edema and serous retinal detachment as initial ocular manifestations of systemic lymphoma: A case report and literature review.

This report describes a unique case of systemic diffuse large B-cell lymphoma (DLBCL) with initial ocular manifestations of bilateral optic disc edema and serous retinal detachment (SRD). A 29-year-old man presented with altered color vision in the left eye, mild fever, weakness, and headache, followed by bilaterally reduced visual acuity. Anterior segment and vitreous examinations showed no inflammation with sluggish response of light reflex.

A STROBE-compliant case-control study: Effects of cumulative doses of topical atropine on intraocular pressure and myopia progression.

Topical atropine has become a mainstream treatment of myopia throughout East and Southeast Asia, but it is uncertain whether long-term topical atropine therapy induces intraocular pressure (IOP) elevation and subsequent development of glaucoma. We then prospectively examined the effects of long-term atropine treatment on IOP.Our case series collected 186 myopic children who were younger than 16 years of age.

Expression Profiling of Exosomal miRNAs Derived from the Aqueous Humor of Myopia Patients.

Myopia is the most common refractive disorder in Eastern Asia. The development of myopia is associated with the cooperation of various ocular tissues. Exosomes in the aqueous humor (AH) have been implicated to modulate intracellular communications by transferring exosomal miRNAs and proteins between cells.

Intraocular lens opacification after Descemet's stripping automated endothelial keratoplasty.

Compared with conventional penetrating keratoplasty, Descemet's stripping automated endothelial keratoplasty (DSAEK) more effectively maintain global integrity and rapid vision rehabilitation with less ocular surface disorders in patients with endothelial dysfunction. Here, we report a case of a 76-year-old woman who experienced opacification of a hydrophilic intraocular lens (IOL) approximately 10 months after DSAEK. The patient with no history of systemic disease developed pseudophakic bullous keratopathy in the right eye 2 years after undergoing cataract surgery.

Surgical treatment of neovascular glaucoma with Ex-PRESS glaucoma shunt: Case report.

Rationale: Neovascular glaucoma (NVG) is one of the most aggressive types of glaucoma, and its abnormal fibrovascular tissue growth on the iris and trabecular meshwork may create difficulties to control the intraocular pressure (IOP) and perform the operation such as trabeculectomy.

Patient Concerns: Ex-PRESS glaucoma shunt has been introduced to serve as one alternative operation for glaucoma, and is thought to have the potential advantage of being less traumatic than traditional trabeculectomy. The purpose of our study is to evaluate the efficacy and safety of primary Ex-PRESS implantation in eyes with NVG.

Regulatory SNPs Alter the Gene Expression of Diabetic Retinopathy Associated Secretary Factors.

Objectives: Diabetic retinopathy (DR) is a common microvascular complication in both type I and type II diabetes. Several previous reports indicated the serum centration of some secretary factors were highly associated with DR. Therefore, we hypothesis regulatory SNPs (rSNPs) genotype in secretary factors may alter these gene expression and lead to DR.

27-GAUGE NEEDLE-ASSISTED TECHNIQUE FOR REPOSITIONING A DISLOCATED INTRAOCULAR LENS.

Background: Several techniques for the reposition of a posterior chamber intraocular lens (IOL) posterior dislocating into the vitreous cavity have been developed. However, most of these methods are complicated or include externalizing part of the IOL from a corneal or scleral wound. We here describe a 27-gauge needle-assisted technique for management of a dislocated posterior chamber IOL.

keratitis treated successfully with topical and oral fluconazole.

A 73-year-old male patient presented with ocular pain, redness, and blurred vision in the left eye, which had been ongoing for more than 2 months. An oval-shaped paracentral corneal ulcer with stromal infiltration and a mild anterior chamber reaction were found. Despite treatment with empiric antibiotics, the lesion progressed and corneal thinning in the middle area was noted.

Ocular decompression retinopathy after laser iridotomy in a patient with acute angle closure.

A 65-year-old female developed elevated intraocular pressure (IOP) with angle closure in the right eye. The fundus examination revealed vitreo-retinal hemorrhage that had occurred after neodymium-doped yttrium aluminum garnet (Nd:YAG) laser iridotomy. The retinal hemorrhage resolved spontaneously.

Subconjunctival Herniated Orbital Fat Mimicking Adipocytic Neoplasm.

Purpose: To describe and discuss rare and benign conditions of subconjunctival orbital fat herniation that may mimic adipocytic neoplasm.

Methods: Sixteen eyes of 13 patients with subconjunctival orbital fat herniation were included. They all underwent transconjunctival excision owing to cosmesis, discomfort, or suspicion of malignancy.

Herpetic keratouveitis mixed with bilateral Pseudomonas corneal ulcers in vitamin A deficiency.

A 56-year-old woman complained of blurred vision and pain in her right eye for several days. Slit lamp examination revealed a large epithelial defect and disciform stromal edema with ring infiltration in her right cornea. Unfortunately, hypopyon and purulent discharge subsequently developed in both eyes.

Atypical Rosai-Dorfman disease with lacrimal gland involvement.

Purpose: Rosai-Dorfman disease is a rare, benign, idiopathic histocytic proliferative disorder that typically presents in young adults with painless cervical lymphadenopathy. Here we report an atypical case of Rosai-Dorfman disease involving orbit tissue and lacrimal gland, unilaterally.

Case: A 69-year-old Asian women developed a painless palpable mass with local edema over the left upper eyelid over several months.

Coenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation.

Recent studies indicate that caspase-2 is involved in the early stages of apoptosis, particularly before the occurrence of mitochondrial damage. Here we report the important role of the coenzyme Q10 (CoQ10) on the activity of caspase-2 upstream of mitochondria in ethanol (EtOH)-treated corneal fibroblasts. After EtOH exposure, cells produce excessive reactive oxygen species formation, p53 expression, and most importantly, caspase-2 activation.

Topiramate use and the risk of glaucoma development: a population-based follow-up study.

Purpose: To investigate the risk of glaucoma development after being prescribed topiramate.

Design: A retrospective, population-based cohort study using an administrative database.

Methods: The study group comprised 1956 patients who received their first prescription of topiramate between 2001 and 2007.

Transient changes of intraocular pressure and anterior segment configuration after diagnostic mydriasis with 1% tropicamide in children.

Background: This study investigated the association of transient changes in intraocular pressure (IOP) with changes in the anterior chamber configuration in children after diagnostic mydriasis with 1% tropicamide.

Methods: In this prospective case-control study, 163 hospital clinic-based samples of unrelated children with or without myopia were enrolled. Complete ophthalmological examinations, including visual acuities, cycloplegic refraction, slitlamp examination, fundus examination, IOP, axial length measurement and Pentacam examination were performed.

Coenzyme Q10 reduces ethanol-induced apoptosis in corneal fibroblasts.

Dilute ethanol (EtOH) is a widely used agent to remove the corneal epithelium during the modern refractive surgery. The application of EtOH may cause the underlying corneal fibroblasts to undergo apoptosis. This study was designed to investigate the protective effect and potential mechanism of the respiratory chain coenzyme Q(10) (CoQ(10)), an electron transporter of the mitochondrial respiratory chain and a ubiquitous free radical scavenger, against EtOH-induced apoptosis of corneal fibroblasts.

Iritis and pupillary distortion after periorbital cosmetic alexandrite laser.

Background: To describe a case of ocular complications associated with laser-assisted periorbital cosmetic treatment and to recommend consideration of the ocular damage caused by dermatological laser therapy, including pupillary distortion and anterior uveitis.

Methods: Case report.

Results: A 29-year-old Caucasian woman underwent cosmetic alexandrite laser therapy in the left upper eyelid area without protective eye shields.

Effects of aging on anterior and posterior corneal astigmatism.

Purpose: To evaluate age-related changes in astigmatism of both corneal surfaces and the whole cornea.

Methods: The right eyes of 370 subjects were measured with a rotating Scheimpflug camera (Pentacam). Astigmatisms of the anterior and posterior corneal surfaces were determined.

Recurrent cytomegalovirus corneal endotheliitis after penetrating keratoplasty.

Purpose: To report a case of recurrent cytomegalovirus (CMV) corneal endotheliitis after penetrating keratoplasty.

Methods: Penetrating keratoplasty (PK) was performed in a 49-year-old man with bullous keratopathy. Pigmented keratic precipitates (KPs) were found in the corneal endothelium of the graft 13 days after surgery, with the subsequent appearance of coin-shaped lesions.

Estimation accuracy of surgically induced astigmatism on the cornea when neglecting the posterior corneal surface measurement.

Purpose: To evaluate the accuracy of corneal surgically induced astigmatism (SIA) estimation when neglecting the posterior corneal surface measurement.

Methods: Fifty right eyes undergoing phacoemulsification were measured with a rotating Scheimpflug camera (Pentacam; Oculus Inc., Wetzlar, Germany) both before and after surgery.

Accuracy of corneal astigmatism estimation by neglecting the posterior corneal surface measurement.

Purpose: To evaluate the accuracy of corneal astigmatism estimation by neglecting the posterior corneal surface measurement.

Design: Prospective, observational study.

Methods: The right eyes of 493 subjects were measured with a rotating Scheimpflug camera (Pentacam; Oculus, Wetzlar, Germany).

Estimation of the effective lens position using a rotating Scheimpflug camera.

Purpose: To describe a no-history method of estimating the effective lens position (ELP) for double-K intraocular lens (IOL) power calculation in eyes that had previous refractive surgery.

Setting: Departments of Ophthalmology, Taipei Medical University Hospital and Taipei City Hospital, Taipei, Taiwan.

Methods: The corneal height (H(m)) and anterior chamber diameter (AG(m)) in 106 unoperated eyes were measured using a rotating Scheimpflug camera.

Detection of hepatitis B virus in the aqueous humor of a hepatitis B virus carrier.

The prevalence of hepatitis B virus (HBV) is particularly high in Asian countries, including Taiwan. Previous studies have reported detection of HBV surface antigens in tears and aqueous humor of HBV-seropositive individuals, suggesting that ophthalmologists may be at risk of contracting HBV infection by treatment of such patients. Herein we report the case of an asymptomatic Taiwanese HBV patient in whom HBV was detected in aqueous humor using PCR.