Preprogramming mechanism of luteinizing hormone in the determination of the lifespan of the rat corpus luteum.

Luteal regression was studied in female rats bearing an isografted pituitary under the renal capsule and the day of ovulation was designated as day 0. These females had pseudopregnancy-like cycles and ovulations at 16-day intervals. After each ovulation, corpora lutea were activated and progesterone concentrations increased in peripheral blood until day 5, after which concentrations gradually decreased.

Holoprosencephaly in human embryos: epidemiologic studies of 150 cases.

One hundred fifty embryos with holoprosencephaly were found among the total of 36,380 conceptuses obtained through induced abortion in the period from 1962 to 1974, giving an overall incidence of 0.4 percent. The occurrence was period from 1962 to 1974, giving an overall incidence of 0.

Intratesticular tissue fluid (ITF) for the micro-bioassay of LH.

Intratesticular tissue fluid (ITF) was obtained by centrifugation of the decapsulated testis of the adult rat. Testosterone level in ITF was increased by direct injection of LH into the testis and was lowered by anti-LH serum. Based on the result of previous reports with testosterone in testicular vein blood, a simplification of the LH bioassay without imparing sensitivity and accuracy was undertaken using ITF as the material for testosterone measurement.