Hydrogen-bonded six-component assembly for capsule formation based on tetra(4-pyridyl)cavitand and isophthalic acid linker and its application to photoresponsive capsule.

Two molecules of tetra(4-pyridyl)cavitand 1 and four molecules of isophthalic acid linker 2a with a triethylene glycol monomethyl ether (TEG) group self-assembled into a six-component capsule 1·2a through eight pyNHOC hydrogen bonds, which encapsulates one molecule of guest G such as bis(4-acetoxyphenyl)acetylene and hexakis(4-iodophenyl)benzene to form G@(1·2a). Guest-encapsulation ability and selectivity of 1·2a were revealed. trans-5-(p-Substituted-phenylazo)isophthalic acid with two dichotomous branching TEG groups trans-2b serves as a photoresponsive linker to form 1·(trans-2b), which moderately reduced guest-encapsulation ability upon photoisomerization (at the photostationary state, 10% guest release upon subunit-trans-2b/subunit-cis-2b = 18 : 82).

1'-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells.

1'-Acetoxychavicol acetate (ACA) is naturally obtained from the rhizomes and seeds of Alpinia galangal. Here, we examined the effect of ACA on learning and memory in senescence-accelerated mice prone 8 (SAMP8). In mice that were fed a control diet containing 0.