A province-level risk factor analysis of fluoroquinolone consumption patterns in Canada (2000-06).

Objectives: To assess potential risk factors among socioeconomic variables and the rate of influenza for the use of different fluoroquinolone antimicrobials in Canada, and to evaluate modelling fluoroquinolone-use data by two different outcome measures.

Methods: Fluoroquinolone use was described monthly from 2000 to 2006 by two outcome measurements: defined daily doses and prescription counts. Multivariable linear and negative binomial models were produced with socioeconomic and influenza rate data.

Canadian province-level risk factor analysis of macrolide consumption patterns (2000-2006).

Objectives: To assess provincial-level predictors among socioeconomic and influenza rate data for the use of different macrolide antimicrobials in Canada from 2000 to 2006.

Methods: Multivariable models were developed to describe macrolide defined daily doses per capita.

Results: Use was highest during October to March for all macrolides.

The effect of transposon Pokey insertions on sequence variation in the 28S rRNA gene of Daphnia pulex.

The goal of this study was to determine the impact of breeding system and the presence of the transposon Pokey on intraindividual variation in 28S rRNA genes. We PCR-amplified, cloned, and sequenced 1000 nucleotides downstream of the Pokey insertion site in genes with and without insertions from 10 obligately and 10 cyclically parthenogenetic isolates of Daphnia pulex. Variation among genes with Pokey insertions was higher than variation among genes without insertions in both cyclic and obligate isolates.