Publications by authors named "Shion Fujii"
Article Synopsis
- - Chondroitin has been found to extend both lifespan and healthspan in the model organism C. elegans, but how it interacts with anti-aging processes inside cells is not fully understood.
- - The study reveals that chondroitin plays a crucial role in aging by promoting the formation of hemidesmosomes and preventing the excessive formation of tubular lysosomes that are linked to aging.
- - A mutation in the gene that produces chondroitin leads to earlier aging signs, specifically through excessive tubular lysosome formation, while the VHA-7 protein helps mitigate the effects of such mutations, indicating a potential new anti-aging mechanism controlled by the extracellular matrix.
Chondroitin, a class of glycosaminoglycan polysaccharides, is found as proteoglycans in the extracellular matrix, plays a crucial role in tissue morphogenesis during development and axonal regeneration. Ingestion of chondroitin prolongs the lifespan of C. elegans.
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