Publications by authors named "Shiomi Ohta"
Article Synopsis
- Mammalian DNA methyltransferases are crucial for restoring DNA methylation patterns during implantation, which is necessary for passing on epigenetic information.
- Zbtb38, a methyl-CpG binding protein, is vital for mouse embryonic stem cell proliferation by regulating Nanog expression, but its in vivo role was previously unclear.
- The study found that loss of Zbtb38 leads to reduced cell proliferation and increased apoptosis in the early embryo, resulting in lethality, showcasing its importance in early development by influencing key genes like Nanog and Sox2.
