Geranylgeranylacetone attenuates septic diaphragm dysfunction by induction of heat shock protein 70.

Objective: The purposes of the present study were to evaluate the induction of heat shock protein (HSP) 70 expression in the diaphragm by geranylgeranylacetone (GGA) administration and to determine the effect of HSP70 induction on diaphragm contractility measured in vitro and the production of oxygen-derived free radicals during experimental septic peritonitis.

Design: Prospective laboratory study.

Setting: University laboratory.