Predictive Value of F-Sodium Fluoride Positron Emission Tomography in Detecting High-Risk Coronary Artery Disease in Combination With Computed Tomography.

Background Application of F-sodium fluoride (F-NaF) positron emission tomography ( PET ) to coronary artery disease has attracted interest. We investigated the utility of F-NaF uptake for predicting coronary events and evaluated the combined use of coronary computed tomography (CT) angiography ( CCTA ) and F-NaF PET /CT in coronary artery disease risk assessment. Methods and Results This study included patients with ≥1 coronary atherosclerotic lesion detected on CCTA who underwent F-NaF PET / CT .

[Effects of the Obesity Type on FDG-PET Image Quality].

Purpose: The aim of our study is to evaluate whether an F-FDG PET/CT image quality is influenced by the obesity type visceral fat or subcutaneous fat.

Methods: We chose continuously 68 patients with obesity (35 subcutaneous fats and 33 visceral fats) who underwent an F-FDG PET/CT scan at our clinic from January 3, 2015 to June 30, 2015. And then, we calculated the noise equivalent count (NEC), the signal to noise ratio of the liver (SNR), and the ratio of random coincidence counts to total prompt (random/prompt countrate) on each PET/CT image.

Data on analysis of coronary atherosclerosis on computed tomography and F-sodium fluoride positron emission tomography.

This article contains the data showing illustrative examples of plaque classification on coronary computed tomography angiography (CCTA) and measurement of F-sodium fluoride (F-NaF) uptake in coronary atherosclerotic lesions on positron emission tomography (PET). We divided the lesions into one of three plaque types on CCTA (calcified plaque, non-calcified plaque, partially calcified plaque). Focal F-NaF uptake of each lesion was quantified using maximum tissue-to-background ratio.

F-sodium fluoride positron emission tomography for molecular imaging of coronary atherosclerosis based on computed tomography analysis.

Background And Aims: We aimed at evaluating the relation of F-sodium fluoride (F-NaF) uptake on positron emission tomography (PET) to coronary atherosclerosis detected and assessed by computed tomography (CT).

Methods: Thirty-two patients with one or more coronary atherosclerotic lesions detected on cardiac CT underwent F-NaF PET/CT. Each coronary atherosclerotic lesion was evaluated on CT angiography for plaque types (calcified plaque [CP], non-calcified plaque [NCP], partially calcified plaque [PCP]), and the presence of CT-based high-risk features (minimum CT density <30 Hounsfield units and vascular remodeling index >1.

[Effects of Non-radioactive Material around Radioactive Material on PET Image Quality].

Purpose: Subcutaneous fat is a non-radioactive material surrounding the radioactive material. We developed a phantom, and examined the effect of subcutaneous fat on PET image quality.

Methods: We created a cylindrical nonradioactive mimic of subcutaneous fat, placed it around a cylindrical phantom in up to three layers with each layer having a thickness of 20 mm to reproduce the obesity caused by subcutaneous fat.

Apparent diffusion coefficient values in peripheral and transition zones of the prostate: comparison between normal and malignant prostatic tissues and correlation with histologic grade.

Purpose: To investigate the utility of apparent diffusion coefficient (ADC) values for discriminating tumor in patients with prostate cancer from normal prostatic tissues in healthy adult men, and to identify correlations between ADC and histologic grade of prostate cancer.

Materials And Methods: A total of 125 healthy male volunteers (mean age, 60 years; range, 50-86 years) and 90 prostate cancer patients (mean age, 71 years; range, 51-88 years) underwent diffusion-weighted imaging (DWI) of the prostate with a single-shot echo-planar imaging sequence using b-factors of 0 and 800 sec/mm2. ADC was measured from two locations in the peripheral zone (PZ) and two locations in the central gland (CG) in normal subjects, and tumor locations of PZ or transition zone (TZ) in patients with prostate cancer.

Age-related and zonal anatomical changes of apparent diffusion coefficient values in normal human prostatic tissues.

Purpose: To identify age-related changes and differences in the diffusion of water molecules within the prostate, through diffusion-weighted imaging (DWI) of the prostate gland in healthy adult Japanese men.

Materials And Methods: A total of 114 healthy male volunteers (mean age, 55 years; range, 24-81 years) underwent DWI of the prostate with a single-shot echo-planar imaging (EPI) sequence using b-factors of 0 and 1000 seconds/mm(2). Apparent diffusion coefficient (ADC) values of six locations in the peripheral zone (PZ) and two locations in the central gland (CG) were measured and correlations between region and age were examined.