Synopsis of recent research by authors named "Shinya Oki"
- Shinya Oki's recent research spans the fields of genetics, epigenetics, and cellular biology, focusing on the underlying mechanisms of various diseases, including microcephaly, cancer predisposition, and atrial fibrillation, by analyzing genetic variants and transcription factors.
- His work emphasizes the interplay between mitochondrial and lysosomal functions, the role of epigenomic landscapes in understanding how pollutants affect gene expression, and the development of data-mining tools like ChIP-Atlas to explore chromatin architecture and regulatory mechanisms.
- Key findings include the identification of pathogenic variants in genes such as BRCA2 and PNPLA8 linked to cancer and neurodegenerative disorders, as well as insights into how cellular stress can activate specific enhancers through retrograde signaling pathways.
