Publications by authors named "Shinya Nakao"
Article Synopsis
- The study aims to find genetic factors that contribute to myopic macular neovascularization (mMNV) in people with severe myopia through a genome-wide association study (GWAS) meta-analysis.
- Researchers analyzed data from 2,783 highly myopic individuals, including 608 with mMNV and 2,175 controls, using advanced genetic analysis techniques.
- The study discovered a new genetic variant, rs56257842, associated with a lower risk of mMNV, and found that certain transcription factors interacted differently with this variant, suggesting it plays a significant role in the disease's development.
Article Synopsis
- The study investigates the relationship between Govetto's staging (stages 1-4) for epiretinal membrane (ERM) and binocular vision, as previous research focused solely on monocular vision.* -
- Researchers analyzed various visual parameters in 28 treatment-naïve patients with unilateral ERM, finding that Govetto's stage correlated significantly with binocular single vision (BSV) and central retinal thickness.* -
- The results indicated that patients without BSV had a more advanced Govetto stage compared to those with BSV, highlighting the staging system's potential in predicting both monocular and binocular visual function.*
Pathological myopia (PM) is one of the leading causes of blindness, especially in Asia. To identify the genetic risk factors of PM, a two-stage genome-wide association study (GWAS) and replication analysis in East Asian populations is conducted. The analysis identified LILRB2 in 19q13.
View Article and Find Full Text PDFBackground/objectives: To investigate whether the corrective effect differs between upward and downward transpositions or between exotropia and esotropia in vertical transposition accompanied by horizontal rectus muscle recession-resection.
Subjects/methods: This prospective study investigated 41 patients with concomitant exotropia or esotropia with small-angle vertical deviation who underwent unilateral vertical transposition accompanied by horizontal rectus muscle recession-resection and were followed up for 1 year postoperatively. We analysed the vertical deviation corrective effect, defined as the corrective amount per displacement distance (°/tendon width [TW]).
Purpose: To investigate the prevalence and incidence of strabismus in the Japanese population by age group and to estimate the subtype proportions.
Design: A nationwide population-based cohort study.
Methods: This study investigated the number of cases with previous and new diagnoses of strabismus by age group between 2009 and 2020 using the National Database of Health Insurance Claims and Specific Health Checkups of Japan, which includes almost all (≥95%) medical claims data.
Purpose: To evaluate the association between the duration of macular detachment (DMD) and visual prognosis in patients with macula-off rhegmatogenous retinal detachment (RD).
Design: Prospective observational cohort study.
Participants: This study analyzed 719 eyes with macula-off rhegmatogenous RD registered with the Japan-Retinal Detachment Registry created by the Japan Retina and Vitreous Society.
Rationale: Pulled-in-two syndrome is one of the significant complications of strabismus surgery. This study aimed to report a case of pulled-in-two syndrome of the contractured medial rectus muscle (MR) that occurred during strabismus surgery for strabismus fixus due to high myopia, and to describe a rescue of this complication.
Patient Concerns: A woman in her 60s presented to our Ophthalmology Department with the main complaint of unilateral high myopia and severe myopic strabismus fixus.
Article Synopsis
- - The study aimed to explore the genetic factors linked to age-related macular degeneration (AMD) specifically within a Japanese population by conducting a genome-wide association study (GWAS).
- - Researchers analyzed data from nearly 4,000 AMD patients and over 16,000 controls, identifying six genetic loci significantly associated with AMD, including two novel loci not previously linked to the disease.
- - The findings also revealed that these novel loci were associated with another eye condition, central serous chorioretinopathy (CSC), suggesting potential shared genetic mechanisms between AMD and CSC.
Purpose: To describe the distribution of ocular biometry and refraction in Japanese adults.
Design: Cross-sectional analysis of a prospective cohort study.
Participants: A total of 9850 individuals participated in the first follow-up of the Nagahama Prospective Cohort for Comprehensive Human Bioscience (the Nagahama Study) conducted between 2013 and 2016.
Strabismologists are eager to identify preoperative or intraoperative strabismus surgery outcome predictors because of the variable effects in each patient. Conjunctival closure position recession after rectus muscle recession is effective for correcting large angle strabismus. The elasticity of the conjunctiva and Tenon's capsule is important for strabismus surgery management.
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