Publications by authors named "Shinya Matsumura"
Article Synopsis
- - Neuroendocrine tumors (NETs) in the ampulla of Vater are uncommon and not much is known about how they develop; a case is presented involving a 44-year-old woman with a 5-mm NET showing lymphatic invasion despite negative surgical margins after endoscopic papillectomy.
- - The patient underwent underwater endoscopic papillectomy (UEP) to remove the tumor, which was confirmed to be a grade 1 NET with no residual disease; however, a pancreaticoduodenectomy was recommended due to concerns about potential lymph node metastasis.
- - Over a follow-up period of 26 months, the patient showed no signs of lymph node metastasis or recurrence, highlighting UEP as a
Article Synopsis
- H. pylori is a known carcinogen linked to gastric cancer, and while eradicating it lowers GC risk, cases of recurrence still occur.
- This study aimed to explore the link between gastric mucosa-associated microbiota (G-MAM) and early gastric cancer (EGC) in patients who successfully got rid of H. pylori at least 5 years prior.
- Results showed significant differences in certain microbial populations between patients with EGC and those without, suggesting that changes in G-MAM may play a role in cancer development even after H. pylori has been eradicated.
Granulocyte-colony stimulating factor (G-CSF) stimulates bone marrow progenitor cell proliferation and enhances neutrophil production. Exogenous G-CSF administration is indicated for chemotherapy-induced neutropenia management. However, there is a paucity of basic research examining the effects of the concomitant use of G-CSF and chemotherapy on myeloid cells in vivo.
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- V-ATPase plays a role in cancer development, and proton pump inhibitors (PPIs) could improve chemotherapy effectiveness for esophageal cancer patients.
- The study tested three PPIs (lansoprazole, esomeprazole, vonoprazan) alongside 5-fluorouracil (5-FU) on esophageal cancer cells and analyzed outcomes in 40 patients who received 5-FU.
- Results showed that PPIs significantly boosted the effectiveness of 5-FU in lab tests, and PPI-treated patients had better overall survival rates compared to those without PPI treatment.
Cancer cachexia and the associated skeletal muscle wasting are considered poor prognostic factors, although effective treatment has not yet been established. Recent studies have indicated that the pathogenesis of skeletal muscle loss may involve dysbiosis of the gut microbiota and the accompanying chronic inflammation or altered metabolism. In this study, we evaluated the possible effects of modifying the gut microenvironment with partially hydrolyzed guar gum (PHGG), a soluble dietary fiber, on cancer-related muscle wasting and its mechanism using a colon-26 murine cachexia model.
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- The study focused on assessing endoscopic findings using linked color imaging (LCI) and blue laser imaging (BLI) to identify diagnostic signs for duodenal adenocarcinomas.
- Researchers analyzed 90 patients with 110 superficial non-ampullary duodenal epithelial tumors, finding distinct colors and patterns indicating higher likelihoods of adenocarcinomas compared to adenomas.
- Key predictors for diagnosing adenocarcinoma included the presence of an orange color sign on LCI and specific mixed or irregular microsurface patterns noted via magnifying BLI.
Article Synopsis
- The study explores how broad-spectrum antibiotics affect glucose transport and metabolism in mice, focusing on the gut microbiota's role in glucose homeostasis.
- Mice were given antibiotics for 4 weeks, leading to increased expression of glucose transporters (SGLT1 and CDX1) and changes in small intestine structure.
- Results showed that antibiotic treatment raised fasting glucose levels, suggesting significant implications for understanding the link between gut health and glucose regulation.
This study evaluated the technical aspects of colorectal endoscopic submucosal dissection (ESD) with the Clutch Cutter (CC) (Fujifilm Co., Tokyo, Japan), a scissor-type knife, and the S-O clip (SO) as a traction clip, and compared the safety and efficacy to ESD using a needle-type knife. This was a single-center retrospective study.
View Article and Find Full Text PDFBackground And Study Aim: This study aimed to evaluate endoscopic findings using non-magnifying blue laser imaging (BLI) to determine the risk factors for metachronous esophageal squamous cell carcinoma (ESCC).
Patients And Methods: All consecutive patients who underwent endoscopic submucosal dissection (ESD) for primary superficial ESCC (SESCC) without a history of ESCC between January 2013 and January 2016 were enrolled. Three highly experienced endoscopists investigated seven endoscopic findings using non-magnifying BLI as follows: (1) a brownish area with unclear margin, (2) white flat deposits, (3) multiple foci of dilated vessels, (4) low capillary permeability, (5) multiple glycogenic acanthosis, (6) horizontal lines, and (7) a nonuniform color tone.
Article Synopsis
- A study in Japan compared the visibility of early gastric cancers (EGCs) and H. pylori-associated gastritis using LED endoscopy versus the traditional laser endoscopy.
- The study evaluated 99 lesions and found that the visibility scores for both types of endoscopy showed non-inferiority, indicating LED endoscopy works comparably well to laser techniques.
- Additionally, linked color imaging (LCI) proved to be more effective than white-light imaging (WLI) for both EGCs and gastritis, making LED endoscopy a viable option for accurate detection.
The visibility and diagnostic accuracy of early gastric cancer (EGC) after (HP) eradication have been reported to improve using image-enhanced endoscopy (IEE) compared with white light imaging (WLI). The present study clarified the appropriate IEE for the detection and diagnosis of EGC in clinical settings. This prospective and cross-sectional study evaluated the visibility of EGC and endoscopic findings of gastric mucosa after successful HP eradication ( = 31) using videos with WLI and IEE.
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- Identifying the depth of invasion (DOI) in superficial esophageal squamous cell carcinoma (SESCC) is essential for deciding if endoscopic resection is needed, with a study comparing the effectiveness of magnifying blue laser imaging (M-BLI) to other imaging techniques.
- The study analyzed 160 patients who underwent endoscopic submucosal dissection, using three types of imaging: white-light imaging (WLI), M-BLI, and magnifying narrow-band imaging (M-NBI), to evaluate DOI accuracy.
- Results showed that combined WLI with M-BLI or M-NBI improved diagnostic accuracy significantly compared to WLI alone, indicating both M-BLI and M-NBI can reliably predict DOI in
Epithelial‑mesenchymal transition (EMT) is considered a crucial event in the development of cancer metastasis. Metformin is a drug used in the treatment of type 2 diabetes. Recently, increasing evidence has indicated that metformin possesses anti‑tumor activities.
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- This study evaluated the safety and feasibility of using a scissors-type knife for endoscopic submucosal dissection (ESD) with over-the-scope clip (OTSC) closure in treating superficial non-ampullary duodenal epithelial tumors (SNADETs).
- Researchers analyzed data from patients who underwent ESD between 2009 and 2019, comparing outcomes between two knife types and different closure methods.
- Results showed that the scissors-type knife had a higher complete resection rate and a lower perforation rate compared to the needle-type knife, indicating that this method is safe and effective for treating SNADETs.
Article Synopsis
- An innovative endoscopic system using 4-color LEDs was introduced in the U.S. and Europe between 2016-2017, aimed at areas where laser endoscopes weren't approved.
- The study compared the effectiveness of this new LED-based imaging (LED-BLI) against traditional laser-based imaging (Laser-BLI) in diagnosing early gastric cancer (EGC).
- Results showed that LED-BLI performs comparably to Laser-BLI in identifying key features of EGC, suggesting it is a viable alternative for accurate diagnosis.
Background: Management of antithrombotic agents during endoscopic treatment changed after the publishing of -Japan Gastroenterological Endoscopy Society guidelines for gastroenterological endoscopy in antithrombotic drug users (GL-2012).
Objectives: We aimed to evaluate the effect of implementing antithrombotic agent management guidelines (GL-2012) on postoperative bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) and on the prevention of thromboembolic events.
Methods: A total of 1,264 patients who underwent ESD for EGC at Kyoto Prefectural University Hospital between June 2002 and March 2017 were enrolled and divided into 2 groups: 621 patients before the publication of GL-2012 (Pre-GL group) and 643 patients after (Post-GL group).
Endoscopic diagnosis of Helicobacter pylori (H. pylori) infection, the most common cause of gastric cancer, is very important to clarify high-risk patients of gastric cancer for reducing morbidity and mortality of gastric cancer. Recently, the Kyoto classification of gastritis was developed based on the endoscopic characteristics of H.
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- Undernutrition and sarcopenia can worsen chemotherapy-related side effects and overall prognosis in cancer; this study focuses on the unclear impact of sarcopenia in advanced esophageal cancer patients.
- The research analyzed data from 31 esophageal cancer patients who received neo-adjuvant chemotherapy; it found that 51.6% had sarcopenia, but toxicity levels were similar in both sarcopenic and non-sarcopenic patients.
- Non-sarcopenic patients had better therapeutic responses to treatment (53.3% vs. 25.0%) and sarcopenia was identified as a significant predictor of poorer pathological response, indicating its importance
Background/aims: The purpose of this study was to evaluate the safety and efficacy of gastric endoscopic submucosal dissection (ESD) using the Clutch Cutter (CC), a scissor-type knife, compared with those of procedures using conventional devices.
Methods: This single-center retrospective study evaluated 237 patients with early gastric cancer: 83 who underwent ESD using the CC group and 154 who underwent ESD using the insulated-tip knife 2 (IT2 group). Clinicopathological features and technical outcomes were compared between the 2 groups using a propensity score-matched analysis.
Purpose: We assessed whether plasma lactate accumulation increased and the lactate threshold (LT) declined when the skin temperature was lowered by whole body skin surface cooling before exercise in cool, but not temperate, conditions, and whether the lowered LT was associated with sympathetic activation or lowered plasma volume (PV) by cold-induced diuresis.
Methods: Ten healthy subjects performed a graded maximal cycling exercise after pre-conditioning under three different conditions for 60 min. Ambient temperature (using an artificial climatic chamber) and water temperature in a water-perfusion suit controlled at 25 and 34 °C in temperate-neutral (Temp-Neut); 25 and 10 °C in temperate-cool (Temp-Cool); and at 10 and 10 °C in cool-cool (Cool-Cool) conditions, respectively.
A 40-year-old man admitted to our hospital with diarrhea underwent abdominal computed tomography (CT) which showed multiple masses in the liver and pancreatic tail. Although there were no abnormal accumulations with fluorodeoxyglucose ((18)F) positron emission tomography (FDG-PET), (68)Ga-DOTATOC-PET/CT detected obvious abnormal accumulations for the both lobes of liver and pancreatic tail tumors. The serum gastrin was markedly high, and liver tumor biopsy demonstrated the presence of malignant cells with round nuclei that were positive for gastrin and somatostatin receptor.
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- * Eleven peptides were identified, with His-Gly-Lys showing the strongest ability to inhibit calcium elevation in vascular smooth muscle cells stimulated by angiotensin II.
- * The research highlighted that specific modifications of the His-Gly-Lys peptide, such as the presence of certain amino acids, contribute to its effectiveness in reducing intracellular calcium levels.