Background: Continuous subcutaneous administration of injectable opioids is simple and effective; however, skin disorders may occur when high opioid dosages are used. Therefore, we investigated opioid injection drugs with a low risk of skin disorders.
Methods: A retrospective study was conducted using the electronic medical records of patients prescribed 1% hydromorphone hydrochloride or 4% morphine hydrochloride with instructions for continuous subcutaneous administration at Shizuoka Cancer Center from January 2017 to December 2021.
Gold ultrathin nanorods (Au UNRs) are anisotropic nanostructures constructed by attaching gold nanoclusters in one dimension. Au UNRs exhibit localized surface plasmon resonance (LSPR) only in the longitudinal direction because their diameter is smaller than the Fermi wavelength of an electron (<2 nm). In this study, we found that the LSPR wavelength of oleylamine-stabilized Au UNRs is blue-shifted simply by mixing with Ag(I).
View Article and Find Full Text PDFGold and silver nanoclusters (NCs) composed of <200 atoms are novel catalysts because their catalytic properties differ significantly from those of the corresponding bulk surface and can be dramatically tuned by the size (number of atoms). Doping with other metals is a promising approach for improving the catalytic performance of Au and Ag NCs. However, elucidation of the origin of the doping effects and optimization of the catalytic performance are hampered by the technical challenge of controlling the number and location of the dopants.
View Article and Find Full Text PDFThis study introduces a plasmonic reduction catalyst, stable only in the presence of air, achieved by integrating Pt-doped Ru nanoparticles on black gold. This innovative black gold/RuPt catalyst showcases good efficiency in acetylene semi-hydrogenation, attaining over 90% selectivity with an ethene production rate of 320 mmol g h. Its stability, evident in 100 h of operation with continuous air flow, is attributed to the synergy of co-existing metal oxide and metal phases.
View Article and Find Full Text PDFBACKGROUND : Anastomotic leakage at the distal anastomotic site after surgery for acute type A aortic dissection (AAD) occasionally leads to malperfusion or false lumen dilatation in the remnant dissected aorta. Open surgery remains the optimal therapy; however, subsequent surgery with re-sternotomy is excessively invasive in elderly and frail patients. CASE PRESENTATION: We report the case of an 81-year-old woman who was treated with chimney thoracic endovascular aortic repair (TEVAR) for anastomotic leakage after ascending aortic replacement for AAD.
View Article and Find Full Text PDFSingle Pd atom doped AuPd clusters stabilized by polyvinylpyrrolidone (AuPd:PVP) were selectively synthesized by kinetically controlled coreduction of the Au and Pd precursor ions. The geometric structure of AuPd:PVP was investigated by density functional theory calculation, aberration-corrected transmission electron microscopy, extended X-ray absorption fine structure analysis, Fourier transform infrared spectroscopy of adsorbed CO, and hydrogenation catalysis. These results showed that AuPd:PVP takes polydisperse but the same atomic arrangements as undoped Au:PVP while exposing all the atoms including the Pd atom on the surface.
View Article and Find Full Text PDFHydrogen spillover, the migration of dissociated hydrogen atoms from noble metals to their support materials, is a ubiquitous phenomenon and is widely utilized in heterogeneous catalysis and hydrogen storage materials. However, in-depth understanding of the migration of spilled hydrogen over different types of supports is still lacking. Herein, hydrogen spillover in typical reducible metal oxides, such as TiO, CeO, and WO, was elucidated by combining systematic characterization methods involving various techniques, kinetic analysis, and density functional theory calculations.
View Article and Find Full Text PDFAdult skeletal muscle is a highly plastic tissue that readily reduces or gains its mass in response to mechanical and metabolic stimulation; however, the upstream mechanisms that control muscle mass remain unclear. Notch signalling is highly conserved, and regulates many cellular events, including proliferation and differentiation of various types of tissue stem cell via cell-cell contact. Here we reveal that multinucleated myofibres express Notch2, which plays a crucial role in disuse- or diabetes-induced muscle atrophy.
View Article and Find Full Text PDFThe purpose of the present study was to examine whether daily intake of edible bird's nest extract reduced ultraviolet-induced damage to skin. Twenty-one female HR-1/Hos mice were divided into control (C, = 7), low-dose (2 mg/kg body weight/day of edible bird's nest extract) (L, = 7), and high-dose (20 mg/kg body weight/day of edible bird's nest extract) (H, = 7) groups. With their left back skin covered with aluminum sheet to prevent exposure, mice were radiated with either ultraviolet A (20 J/cm) or ultraviolet B (40 mJ/cm) in an alternate manner once daily for 10 weeks.
View Article and Find Full Text PDFSynthesis of an atomically precise Au cluster catalyst was attempted by long-term, low-temperature aging of Au(BaET) (BaET-H = 2-(Boc-amino)ethanethiol) on various double metal hydroxide (DMH) supports. X-ray absorption fine structure analysis revealed that bare Au clusters with high loading (1 wt%) were successfully generated on the DMH containing Co and Ce (CoCe) by oxidative aging in air at 150 °C for >12 h. X-ray absorption near-edge structure and X-ray photoelectron spectroscopies showed that the Au clusters on CoCe were positively charged.
View Article and Find Full Text PDFWe successfully introduced up to 12 poly(benzyl ether)dendron-thiols of the second generation (D2SH) into the Au core of [Au(ScCH)] while retaining the geometric structure. The decoration with D2SH enhanced the optical absorbance in the >2.5 eV region and the quantum yield of photoluminescence at ∼1.
View Article and Find Full Text PDFJ Vasc Surg Cases Innov Tech
December 2021
A 23-year-old woman was diagnosed with a posterior tibial vein aneurysm that had resulted in deep vein thrombosis and a pulmonary embolism. The patient responded well to anticoagulation therapy, and surgical resection was planned to prevent recurrence. She was scheduled to undergo tangential aneurysmectomy and lateral venorrhaphy.
View Article and Find Full Text PDFGen Thorac Cardiovasc Surg
January 2022
Objectives: To date, assessment of nutritional and frailty status in patients undergoing surgical aortic valve replacement remains unclear. This study aimed to assess the effect of geriatric nutritional risk index (GNRI) and Rockwood clinical frailty scale (CFS) on short-term and mid-term survival in patients who underwent surgical aortic valve replacement for aortic stenosis.
Methods: In total, 219 patients who underwent aortic valve replacement for aortic stenosis between Jan 1 2011 and Dec 31 2018 were retrospectively monitored in a single center.
Objectives: To assess the efficacy of preoperative bilateral paravertebral block (PVB) with general anesthesia (GA) in contributing to early extubation and decreasing opioid consumption in cardiac surgery.
Design: A propensity score-matched retrospective study.
Setting: A single tertiary medical center between January 2018 and December 2020.
Nanoparticles of intermetallic compounds have attracted much interest because they can exhibit novel electronic and catalytic properties due to their specific crystal structure, ordered atomic arrangement, and quantum effect. Here, gold-tin (AuSn) bimetallic nanoparticles with various mixing ratios were prepared by a co-reduction method using various protective agents (e.g.
View Article and Find Full Text PDFWe describe the case of a 66-year-old man with a thoracoabdominal aortic aneurysm, who presented with cardiac failure; he had complained of shortness of breath. A contrast-enhanced computed tomography scan and transthoracic echocardiography showed compression of the left atrium and ventricle by a giant thoracoabdominal aortic aneurysm. The cardiac failure resolved after early prosthetic graft replacement surgery.
View Article and Find Full Text PDFAsian Cardiovasc Thorac Ann
June 2020
Primary pulmonary intimal sarcoma is rare. Differentiating it from pulmonary thromboembolism is difficult because of similarities in clinical symptoms and imaging findings. Positron-emission tomography-computed tomography has been useful for diagnosing primary pulmonary intimal sarcoma.
View Article and Find Full Text PDFThis work demonstrated the use of TiO as a promising platform for the synthesis of non-equilibrium RhCu binary alloy nanoparticles (NPs). These metals are regarded as immiscible based on their phase diagram but form NPs with the aid of the significant hydrogen spillover on TiO with concurrent proton-electron transfer. The resulting RhCu/TiO exhibited 2.
View Article and Find Full Text PDFThe hydrogen isotope deuterium is widely used in the synthesis of isotopically-labeled compounds and in the fabrication of semiconductors and optical fibers. However, the facile production of deuterium gas (D) and hydrogen deuteride (HD) in a controlled manner is a challenging task, and rational heterogeneously-catalyzed protocols are still lacking. Herein, we demonstrate the selective production of hydrogen isotope compounds from a combination of formic acid and DO, through cooperative action by a PdAg nanocatalyst on a silica substrate whose surface is modified with amine groups.
View Article and Find Full Text PDFObjectives: Stentless bioprosthetic valves provide hemodynamic advantages over stented valves as well as excellent durability. However, some primary tissue failures in bioprostheses have been reported. This study was conducted to evaluate the morphometrical and biomechanical properties of the stentless Medtronic Freestyle™ aortic root bioprosthesis, to identify any arising problem areas, and to speculate on a potential solution.
View Article and Find Full Text PDFAims: The protein myostatin is a member of the transforming growth factor β superfamily. This is mainly expressed in skeletal muscle and negatively regulates skeletal muscle growth. The present study aimed to elucidate the associations among circulating myostatin level, skeletal muscle mass, and metabolic profiles in Japanese obese patients.
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