Publications by authors named "Shinya Kuwashiro"
Article Synopsis
- A retrospective study analyzed 154 patients with unresectable hepatocellular carcinoma (HCC) to identify factors that predict the effectiveness of the treatment combination of atezolizumab and bevacizumab (atezo/bev).
- In patients with high levels of alpha-fetoprotein (AFP), a notable decrease in AFP levels was linked to a better treatment response. Conversely, in patients with low AFP levels, a baseline des-gamma-carboxy prothrombin (DCP) level below a certain threshold was a positive indicator.
- Additionally, an increase in AFP levels after three weeks and the presence of extrahepatic spread were linked to worse outcomes in the high-AFP group, while certain criteria known as
Purpose: We previously developed medaka non-alcoholic steatohepatitis (NASH) model. The model showed similar histology with human NASH so we analyzed the effect of drug using medaka NASH activity score (MNAS). In this study we analyzed the effect of ezetimibe, a small intestine cholesterol transporter inhibitor, on NASH.
View Article and Find Full Text PDFWe investigated the efficacy of the antihypertensive drug telmisartan (Tel) and the mechanisms underlying the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) in a medaka (Oryzias latipes) NASH model. We used the NASH activity score (NAS) developed in humans to assess the histology of the medaka NASH model and found that NAS increased with time. Further, TUNEL-positive apoptosis hepatocytes were found in the medaka NASH model.
View Article and Find Full Text PDFThe global incidence of nonalcoholic steatohepatitis (NASH) is increasing and current mammalian models of NASH are imperfect. We have developed a NASH model in the ricefish medaka (Oryzias latipes), which is based on feeding the fish a high-fat diet (HFD). Medaka that are fed a HFD (HFD-medaka) exhibited hyperlipidemia and hyperglycemia, and histological examination of the liver revealed ballooning degeneration.
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