Publications by authors named "Shinwon Hwang"
Purpose: TP53 mutations are common in head and neck squamous cell carcinoma (HNSCC). We evaluated their clinical impact in patients treated with targeted agents or immunotherapy in the KCSG HN15-16 TRIUMPH trial.
Materials And Methods: We analyzed clinical characteristics and outcomes of patients with TP53 mutations in the TRIUMPH trial, a multicenter, biomarker-driven umbrella trial in Korea.
Article Synopsis
- EGFR-variant non-small cell lung cancer (NSCLC) is prone to central nervous system (CNS) metastases, making new treatment options like lazertinib important for improving patient outcomes.
- This study was a phase 2 trial in South Korea involving patients with NSCLC and existing brain metastases who had not responded to first or second-generation EGFR inhibitors, assessing lazertinib's effectiveness.
- Results showed a 55% intracranial objective response rate (iORR) for patients, with higher responses in those with specific genetic markers, indicating that lazertinib could be a promising option for treating CNS metastases in these patients.
Article Synopsis
- - This study investigated a targeted treatment approach for patients with platinum-refractory recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) through a genomic profile-based trial involving multiple treatment arms.
- - Patients were assigned to different treatment groups based on their genetic profiles, with various inhibitors used, and crossover to an anti-PD-L1 treatment was allowed if their initial therapy failed.
- - The trial enrolled 203 patients and found varying levels of disease control and response rates across different arms, while the treatments were generally well-tolerated with no treatment-related deaths reported.
Article Synopsis
- Scientists studied tiny changes in our DNA that happen naturally as we grow, looking at samples from 190 people and 498 different organs.
- * They found that early DNA changes were less common but had a bigger impact compared to later changes, which were more specific to certain organs and tissues.
- * The research also showed that brain changes had a special pattern, giving us new ideas about how these DNA changes work depending on when and where they happen in our bodies.
Article Synopsis
- * Nine patients who underwent three to seven TFL sessions showed varying degrees of clinical improvement, with a significant overall reduction in pigmentation severity as measured by dermatologists.
- * No serious treatment-related side effects were noted, suggesting TFL is a promising option for managing Riehl's melanosis, with only minor transient effects like erythema and swelling.
Article Synopsis
- The study explores the effectiveness and safety of using Fractional Microneedle Radiofrequency (FMR) combined with a Thulium Fiber Laser (TFL) for skin rejuvenation specifically targeting wrinkles.
- Twenty-five patients received either FMR alone or a combination of FMR and TFL on opposite sides of their faces, with evaluations done before and after treatment.
- Results showed that the combination treatment led to significantly greater improvements in both patient and investigator assessments of wrinkles compared to FMR alone, indicating a synergistic effect of the two treatments.
Article Synopsis
- - Extracellular ATP, released from keratinocytes due to oxidative stress, plays a significant role in melanocyte degeneration in vitiligo by activating the inflammasome pathway.
- - Increased ATP levels in vitiligo-affected skin lead to heightened ROS production and melanocyte death, along with activation of caspase-1 and inflammatory cytokines IL-1β and IL-18.
- - The study suggests that targeting the ATP/P2X7 signaling pathway could be a viable treatment strategy for vitiligo, as it influences the infiltration of CD8 T cells through the chemokine CXCL9.
Article Synopsis
- Autophagy is a process that helps cells break down and remove unnecessary or damaged components, and it plays significant roles in melanocyte biology, impacting skin coloration and melanin production.
- Recent research shows that activating autophagy can enhance melanosome production and degradation in melanocytes, which are the cells responsible for producing pigment in the skin.
- The use of the synthetic autophagy inducer PTPD-12 in human cells led to increased melanosome degradation and a noticeable lightening of cell color, indicating that controlling autophagy could influence skin pigmentation without affecting melanin production pathways.
Purinergic signaling participates in skin physiology and pathology, such as hair growth, wound healing, inflammation, pain, and skin cancer. However, few studies have investigated the involvement of purinergic signaling in skin pigmentation. This study demonstrated that extracellular adenosine 5'-triphosphate (ATP) released from keratinocytes by UVB radiation promotes melanin production in primary human epidermal melanocytes and ex vivo skin cultures.
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- Phytophotodermatitis is a skin condition caused by contact with certain plants that contain phototoxic substances, followed by ultraviolet light exposure.
- It often appears as red patches on the skin, sometimes with blisters, but can also manifest as sudden dark spots without prior inflammation, particularly in darker-skinned individuals.
- Accurate diagnosis requires careful patient history, especially when noting abrupt hyperpigmentation on sun-exposed skin, to prevent unnecessary testing and treatment.
Severe alopecia areata (AA) can have an unpredictable clinical course and become refractory to contact immunotherapy. Novel treatment options include low-dose interleukin-2 and Janus kinase inhibitors; however, these treatments are still under investigation. Therefore, we evaluated the efficacy and safety of intramuscular (i.
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