Analysis of the association between the rs3759223 variant and high myopia in a Japanese population.

Purpose: Many studies have investigated the relationship of the lumican gene () rs3759223 variant with the risk of high myopia, but the results have been inconsistent and inconclusive. In this study, we investigated whether rs3759223 is associated with high myopia in a Japanese population.

Methods: We recruited 1,585 Japanese patients with high myopia (spherical equivalent [SE] <-9.