Publications by authors named "Shintaro Okamoto"

Article Synopsis
  • LCZ696 (sacubitril/valsartan) has cardioprotective effects and may improve endothelial function in diabetes, which needs further investigation.
  • In a study on diabetic mice, both LCZ696 and valsartan lowered blood pressure and improved endothelium-dependent vascular relaxation, but only LCZ696 enhanced eNOS and Akt phosphorylation.
  • The results indicate that LCZ696 improves diabetes-induced endothelial dysfunction by increasing atrial natriuretic peptide bioavailability, suggesting it may be more effective than valsartan for vascular protection in diabetes.
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As the size of semiconductor devices continues to shrink, the normally random distribution of the individual dopant atoms within the semiconductor becomes a critical factor in determining device performance--homogeneity can no longer be assumed. Here we report the fabrication of semiconductor devices in which both the number and position of the dopant atoms are precisely controlled. To achieve this, we make use of a recently developed single-ion implantation technique, which enables us to implant dopant ions one-by-one into a fine semiconductor region until the desired number is reached.

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