Heterodox modeling: practicing well-tuned provisioning or commoning with networked multi-agent environments.

Market-driven, profit-oriented, mainstream neoclassical economics is increasingly being challenged by alternative approaches such as heterodox economics. This article contributes to broader discussions in this field, especially of social provisioning, and suggests that integrating perspectives from the overlapping fields of media history and history of economy could not only provide valuable insights and attract more supporters, but even initiate a bottom-up transformation process. Historical knowledge regarding how neoclassical economics gained mainstream status in the early postwar decades provides hints on how to popularize non-profit-driven, well-designed approaches to social provisioning, often referred to as commoning.

Mechanism of interdigitation formation at apical boundary of MDCK cell.

It has been reported that the MDCK cell tight junction shows stochastic fluctuation and forms the interdigitation structure, but the mechanism of the pattern formation remains to be elucidated. In the present study, we first quantified the shape of the cell-cell boundary at the initial phase of pattern formation. We found that the Fourier transform of the boundary shape shows linearity in the log-log plot, indicating the existence of scaling.

Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability.

Catalytically inactive Cas9 (dCas9) has become an increasingly popular tool for targeted gene activation/inactivation, live-cell imaging, and base editing. While dCas9 was reported to induce base substitutions and indels, it has not been associated with structural variations. Here, we show that dCas9 impedes replication fork progression to destabilize tandem repeats in budding yeast.

Myrsinoic acid E, an anti-inflammatory compound from Myrsine seguinii.

The methanolic extract of Myrsine seguinii yielded the novel anti-inflammatory compound, myrsinoic acid E (1), whose structure was elucidated to be 3,5-digeranyl-4-hydroxy benzoic acid. We synthesized 1- and its 3,5-diprenyl (2) and 3,5-difarnesyl analogues (3). Compounds 1-3 suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation of mouse ears by 59%, 14%, and 69% at a dose of 1.

Myrsinoic acids B, C and F, anti-inflammatory compounds from Myrsine seguinii.

The methanolic extract of Myrsine seguinii yielded three anti-inflammatory compounds, myrsinoic acids B, C and F, and their structures were elucidated from the spectroscopic data. These compounds suppressed the TPA-induced edema of mouse ear, myrsinoic acid F being the most active (IE 77% at a dose of 0.56 micromol).