Comparison of the Effects of Timolol, Brinzolamide, Brimonidine and Netarsudil in a Rabbit Model of Water Loading-Induced Ocular Hypertension.

Purpose: This study aimed to compare the intraocular pressure (IOP)-lowering effects of timolol (a β-blocker), brinzolamide (a carbonic anhydrase inhibitor), brimonidine (an α2-agonist) and netarsudil (a rho kinase inhibitor) in rabbits.

Methods: The experiments were performed on 52 female New Zealand white rabbits. The IOP was measured in normotensive rabbits and in water loading-induced ocular hypertension model rabbits.

Regulation of human corneal epithelial mucins by rebamipide.

Purpose: Membrane-associated mucins (MAMs) play important roles in barrier function and tear stability, and their expression on the ocular surface is altered in dry eye disease. Rebamipide is a mucin secretagogue that promotes the production of mucin-like glycoproteins in human corneal epithelial (HCE) cells. However, the expression of MAMs on the corneal epithelia (MUC1, MUC4, MUC16), which is induced by rebamipide, is poorly understood.

Investigation of capsaicin-induced superficial punctate keratopathy model due to reduced tear secretion in rats.

Purpose: The present study investigated the usefulness of the superficial punctate keratopathy (SPK) model due to reduced tear secretion induced by the injection of capsaicin in neonatal rats.

Methods: On postnatal day 4, rats were injected subcutaneously with a single dose of capsaicin. Ocular surface symptoms were evaluated by measuring corneal sensitivity, tear secretion and corneal fluorescein score.