Publications by authors named "Shinnosuke Nomura"
Sleep is regulated by homeostatic processes, yet the biological basis of sleep pressure that accumulates during wakefulness, triggers sleep, and dissipates during sleep remains elusive. We explored a causal relationship between cellular synaptic strength and electroencephalography delta power indicating macro-level sleep pressure by developing a theoretical framework and a molecular tool to manipulate synaptic strength. The mathematical model predicted that increased synaptic strength promotes the neuronal "down state" and raises the delta power.
View Article and Find Full Text PDFArticle Synopsis
- Genetically encoded fluorescent sensors are being enhanced to assess cortical activity in non-human primates, allowing for detailed measurements of brain dynamics.* -
- The Automated Robotic Virus injection System (ARViS) was developed to facilitate the precise delivery of biosensors across different cortical areas, utilizing image recognition to avoid blood vessels and enabling precise micropipette insertion.* -
- ARViS demonstrated its effectiveness by successfully injecting biosensors into 266 sites in a marmoset's frontoparietal cortex and enabling advanced imaging techniques to observe cortical activity.*
Unlabelled: We present a case of a ruptured mycotic coronary aneurysm effectively treated with covered stents and phased surgery. The covered stent, however, became occluded two years later. Because of the low invasiveness, a covered stent treatment may be advantageous over conventional surgery but trade off long-term vascular patency.
View Article and Find Full Text PDFUnlabelled: A 71-year-old man was transferred urgently to our hospital after collapsing near his home post the first shot of the BNT162b2 coronavirus disease 2019 vaccine (Pfizer-BioNTech, Comirnaty®). Immediately after arrival at our hospital, cardiac arrest due to complete atrioventricular block with no ventricular escaped beats was observed on electrocardiogram. Echocardiography showed preserved left ventricular ejection fraction, however, diffuse severe hypokinesia was revealed after 3 weeks, and he died 3 months after admission because of worsening heart failure.
View Article and Find Full Text PDFA 77-year-old woman with symptomatic paroxysmal atrial fibrillation (PAF) underwent pulmonary vein isolation (PVI), but subsequently experienced recurrence. In the second session, unidirectional left atrium (LA)-left superior pulmonary vein (LSPV) conduction was revealed to exist at the carina of the LSPV. Left pulmonary vein (LPV) pacing performed in a cycle between 300 and 260 ms revealed rate-dependent pulmonary vein (PV)-LA conduction, and the location was estimated to be in the roof of the LSPV.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how to improve the anchoring of balloons in percutaneous coronary intervention (PCI) by evaluating the factors that affect static friction forces between the balloon and the vessel wall.
- It utilizes a simulated vessel model to test various balloon sizes and properties, finding that longer balloons and higher inflation pressures enhance friction, but increasing balloon diameter does not.
- Additionally, using a jailing coil wire significantly boosts the friction force, suggesting that balloon length, inflation pressure, and the type of wire used can optimize the balloon anchoring technique.