We compared the clinical and radiographic outcome of 15 hips converted to total hip arthroplasty after failed transtrochanteric rotational osteotomy (THA after TRO) for avascular necrosis of the femoral head (ANFH) with that of a matched control group of 16 hips with primary THA for ANFH. The operating time in THA after TRO was significantly longer than that in primary THA. Perioperative blood loss in THA after TRO was significantly more than that in primary THA.
View Article and Find Full Text PDFEctopic bone formation around the poly-L-lactide (PLLA) screw head in eccentric rotational acetabular osteotomy for hip dysplasia was investigated. A total of 174 hips in 165 patients with hip dysplasia were consecutively treated with eccentric rotational acetabular osteotomy. Average age at the time of operation was 37 years.
View Article and Find Full Text PDFThe purpose of this study was to establish the age-related reference values of the platform measures of balance, which would serve as a baseline for comparing the postural insecurity of patients, and to clarify the characteristics of balance in community-dwelling elders. A total of 343 participants consisting of 107 males and 236 females, aged 55--83 years, were investigated in this study. The movement of the center of pressure (COP) was measured using a stable force platform to quantify postural stability.
View Article and Find Full Text PDFBone resorption is regulated by cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and by the balance of a receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG). The aim of this study was to investigate the mechanism of particle-induced osteolysis in murine calvariae by assessing the extent of osteolysis and the expression of inflammatory cytokines, RANKL and OPG after implantation of metal and polyethylene particles. The murine calvariae implanted with Ti6Al4V, CoCr or high-density polyethylene (HDP) particles showed significantly more extensive osteolysis and elevated levels of inflammatory cytokines.
View Article and Find Full Text PDFThis study was conducted to evaluate the usefulness of osteochondral allografts for articular cartilage defects. Cartilaginous defects measuring 4.5 mm in diameter were experimentally prepared in both the weight-bearing and non-weight-bearing regions of the femur in six male miniature pigs (9 months old).
View Article and Find Full Text PDFPeriprosthetic osteolysis is a serious problem that limits long-term survival of total hip arthroplasty. Ceramics have been introduced as a joint surface material to reduce osteolysis due to wear particles. The aim of this study is to investigate the biological reaction of ceramic particles on murine calvarial bone, in comparison with polyethylene and titanium particles.
View Article and Find Full Text PDFThe purpose of this study was to examine quality of life (QOL) after a rotational acetabular osteotomy (RAO), primary total hip arthroplasty (THA), or conservative treatment (Conservative). A series of 147 patients with osteoarthritis of the hip were grouped according to treatment into the RAO group ( n = 62), THA group ( n = 40), and Conservative group ( n = 45) (treated with medication and rehabilitation alone). The mean age of the RAO group was 40 years, the THA group 54 years, and the Conservative group 50 years.
View Article and Find Full Text PDFThe long-term degradation tissue response to poly-L-lactide (PLLA) screw was investigated for a minipig tibia fracture. As a bone-fracture model, three PLLA screws per animal were used to fix a tibia that had been subjected to a crank-shaped osteotomy. A total of 12 nine-month-old male minipigs were used.
View Article and Find Full Text PDFThe control of extracellular matrix (ECM) production is important for the development, maintenance, and repair of cartilage tissues. Matrix molecule synthesis is generally regulated by the rate of gene transcription determined by DNA transcription factors. We have shown that transcription factors Sox9, AP-2, and [delta]EF1 are able to alter the rate of CD-RAP transcription in vitro: Sox9 upregulates, AP-2 exhibits biphasic effects, and [delta]EF1 represses expression of the CD-RAP gene.
View Article and Find Full Text PDFBiochem Biophys Res Commun
May 2002
Basic fibroblast growth factor (bFGF) is reported to stimulate repair of fracture and bony defects in in vivo animal studies. However, most studies performed in vitro demonstrate inhibitory effect of bFGF on cartilage and bone differentiation. To understand the discrepancy observed in in vivo and in vitro studies, we evaluated the effect of bFGF on chondro-osteogenesis initiated by bone matrix powder (MP).
View Article and Find Full Text PDFClin Orthop Relat Res
February 2002
The recognition that demineralized bone matrix could induce bone formation when placed in mammalian skeletal muscle led to preclinical studies of crude native insoluble bone morphogenetic protein and noncollagenous protein, followed by the clinical application of demineralized bone matrix, chemosterilized autolyzed antigen-extracted allogenic bone, and autolyzed antigen-extracted allogenic bone matrix gelatin. Cultural norms and regulatory agencies influence the availability of different demineralized bone matrix preparations in different parts of the world, but there is continued interest in the biologic structure of native insoluble bone morphogenetic protein and noncollagenous protein aggregates and the applied science of osteoinduction and osteoconduction in reconstructive orthopaedic surgery. Demineralized bone matrix is not widely available in Asia, but tissue processing facilities in the United States distribute demineralized bone matrix materials with different carriers, handling properties, and possibly osteoinductive potential.
View Article and Find Full Text PDFBackground: Eccentric rotational acetabular osteotomy for the operative treatment of acetabular dysplasia consists of a spherical but eccentric osteotomy and rotation of the acetabulum that moves the center of rotation of the head of the femur medially and distally. No bone graft is needed. The reorientation of the acetabular fragment not only improves acetabular coverage but also restores the center of rotation of the subluxated hip.
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