Association between nocturnal falls and hypnotic drug use in older patients at acute care hospitals.

Purpose: Although hypnotic drug use is a known risk factor for falls, few reports have analyzed fall risk associated with individual hypnotic drugs after adjusting for confounding factors. While it is recommended that benzodiazepine receptor agonists not be prescribed for older adults, it is unknown whether melatonin receptor agonists and orexin receptor antagonists are safe in this population. Here, we aimed to assess the influence of various hypnotic drugs on fall risk in older patients admitted to acute care hospitals.

A case of delayed diagnosis of Becker muscular dystrophy due to underlying developmental disorders.

Background: Developmental disorders associated with Becker muscular dystrophy (BMD), possibly resulting from a lack of dystrophin in the brain, have been reported, but their importance is not fully understood. We report a case of a BMD patient who had been socially withdrawn due to mental retardation and autism spectrum disorder and could not receive appropriate medical services, resulting in delayed detection of severe cardiomyopathy and embolic strokes which developed as complications of BMD.

Case Report: The case is a 41-year-old male.

[Intravascular Large B-cell Lymphoma].

Intravascular large B-cell lymphoma is an extranodal large B-cell lymphoma characterized by the selective growth of tumor cells in small vessels. It is often difficult to diagnose because of its various and non-specific manifestations. A key to diagnosis is an understanding of how to suspect this disease and performing tissue diagnoses including random skin biopsy.

[Amyotrophic lateral sclerosis with muscle weakness and dropped head during the course of Parkinson's disease: an autopsy case].

A 64-year-old female developed Parkinson's disease at the age of 52 years. She experienced muscle weakness in the upper right extremities and dropped head at 62 and 63 years, respectively; both symptoms were considered to be associated with Parkinson's disease (PD). The dosage of L-DOPA was increased from 200 mg/day to 900 mg/day; however, her neurological symptoms did not improve.

A novel chiral porous metal-organic framework: asymmetric ring opening reaction of epoxide with amine in the chiral open space.

A novel chiral metal-organic framework, [Cu(2)(5,5'-BDA)(2)] was synthesized by treating chiral 2,2'-dihydroxy-1,1'-binaphthalene-5,5'-dicarboxylic acid (5,5'-H(2)BDA) with a Cu(II) ion, in which the asymmetric ring opening reaction of an epoxide with amine proceeds efficiently under solvent-free conditions.