Publications by authors named "Shinji Mito"
Introduction: The clinical efficacy of left bundle branch area pacing (LBBAP) has not been fully elucidated in patients with atrioventricular block and mild to moderately reduced left ventricular ejection fraction (LVEF). This study evaluated the impact of LBBAP on patients with an LVEF of ≤50% and dependent on ventricular pacing.
Methods And Results: Thirty-seven patients with atrioventricular block underwent successful LBBAP.
Article Synopsis
- - Older adults (≥80 years) with acute myocardial infarction (AMI) experience more severe clinical symptoms and worse outcomes compared to younger patients (≤79 years), including higher rates of in-hospital mortality and major adverse cardiovascular events (MACE).
- - Despite similar rates of primary percutaneous coronary intervention (PCI) between the age groups, frail patients aged over 80 showed significantly poorer clinical outcomes than their non-frail counterparts.
- - Early invasive interventions like PCI may improve short-term survival in octogenarians and nonagenarians, even though they present with more severe conditions compared to younger patients.
Background: Left bundle branch area pacing (LBBAP) is a novel conduction system pacing technique. In this multicenter study, we aimed to evaluate the procedural success, safety, and preoperative predictors of procedural failure of LBBAP.
Methods: LBBAP was attempted in 285 patients with pacemaker indications for bradyarrhythmia, which were mainly atrioventricular block (AVB) (68.
Article Synopsis
- - A 63-year-old man with hypertrophic cardiomyopathy experienced cardiac arrest from sustained ventricular tachycardia and received an implantable cardioverter-defibrillator (ICD) for treatment.
- - After multiple episodes of ventricular tachycardia and a refractory electrical storm, he underwent successful epicardial catheter ablation but faced recurrence, leading to surgical intervention.
- - For patients with hypertrophic cardiomyopathy and apical aneurysms, while ICDs are essential for preventing sudden death, surgical resection of apical aneurysms proves to be more effective than alternative treatments for managing refractory electrical storm.
Background: To investigate the anatomical features related to the failure of cryoballoon (CB) ablation for atrial fibrillation (AF) on pre-procedural CT images.
Methods: We retrospectively analyzed CT images of 100 patients with AF who had undergone a first CB ablation at our institution between June 2016 and April 2017. We measured the angle, short- and long axis length, and the area and ovality of 4 major pulmonary vein (PV) ostium on CT images.
Article Synopsis
- - The study examined the atrial arrhythmogenic features in patients with Brugada syndrome, comparing them to a control group and patients with paroxysmal atrial fibrillation (PAF) using a technique called signal-averaged electrogram (SAECG).
- - Results showed that the filtered P wave duration (fPd) was significantly longer in PAF patients compared to both the control and Brugada groups, while the Brugada group had a fPd that was longer than the control but shorter than the PAF group.
- - The findings suggest that patients with Brugada syndrome display abnormal P waves on the SAECG, indicating their P wave characteristics are intermediate between healthy individuals and those with PAF. *
Ganglionated plexus (GP) plays an important role in the initiation and maintenance of atrial fibrillation (AF). The GP ablation has been found to be effective for AF treatment. In this case, we reported an AF case in which the pulmonary vein (PV) potentials of the anterior region of the left superior PV were eliminated by an inferior right GP ablation.
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- - The study examined the importance of measuring lactate levels in patients diagnosed with acute decompensated heart failure (ADHF) admitted to the ICU between 2007 and 2012.
- - Out of 754 patients, 12% died during hospitalization, and higher lactate levels (especially over 3.2mmol/l) were significantly associated with an increased risk of in-hospital mortality, regardless of whether patients had acute coronary syndrome (ACS).
- - The findings suggest that initial lactate levels can be used as an independent predictor of early mortality risk in ADHF patients, indicating the need for routine monitoring in critical care settings.
Objective: The optimal medication therapies are recommended in patients with coronary artery disease even after the coronary revascularization. However, the information of optimal medical therapy in dialysis population is scant. We assessed the efficacy of statin on the clinical outcomes after Sirolimus-eluting stent (SES) implantation in patients with and without dialysis.
View Article and Find Full Text PDFBackground: The current development of serological biomarkers allows detection of smaller myocardial necrosis and early acute myocardial infarction (AMI). We evaluated the relevance of the heart-type fatty acid binding protein (H-FABP) assay, which has recently been approved in Japan, for early diagnosis of AMI as compared with the sensitive troponin assay.
Methods: This is an observational study in a single center.
Article Synopsis
- A 46-year-old woman arrived at the hospital with worsening shortness of breath and swelling in her legs, which had persisted for three months.
- Her medical history included a surgical procedure for a patent ductus arteriosus (PDA) at age 25.
- After an echocardiogram revealed heart issues, she underwent a minimally invasive procedure to close the PDA, resulting in significant improvements in her heart function and size six months later.
Aims: To investigate the clinical outcomes of paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) in patients on dialysis.
Methods And Results: Between May 2004 and December 2008, 95 patients on dialysis with 124 lesions were treated with PES alone, and were compared to 184 patients on dialysis with 244 lesions treated with SES alone, retrospectively. One-year major adverse cardiac event (MACE) including stent thrombosis, target lesion revascularisation (TLR), myocardial infarction (MI) and cardiac death were compared.
Stenosis of the left main coronary artery (LMCA) due to extrinsic compression, producing symptoms of myocardial ischemia, is called left main compression syndrome. We report on a 43-year-old male with acute coronary syndrome who developed left main compression syndrome while waiting for a lung transplantation secondary to interstitial pneumonia, but underwent successful LMCA stenting as emergent treatment. Coronary angiography 3 months after the operation showed good stent patency in the LMCA, and the clinical course was favorable.
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- - The study aimed to investigate whether administering adenosine triphosphate (ATP) during reperfusion after a heart attack could improve heart function in patients who underwent coronary recanalization.
- - In a trial with 27 patients, ATP was given to 16 people while 11 received normal saline; their heart wall motion was assessed using echocardiography before and after the procedure.
- - Results showed that while there was slight recovery in heart function shortly after the procedure in the control group, ATP administration did not significantly improve heart function by 10 days post-procedure, suggesting it may not help reduce myocardial stunning after a heart attack.
Article Synopsis
- The study investigated whether removing the Bach1 gene would help reduce atherosclerosis in mice that also lack the Apo E gene, specifically by creating Apo E/Bach1 double knockout (DKO) mice.
- The results showed that DKO mice had a 32% reduction in atherosclerotic plaques compared to Apo E knockout mice, with increased levels of heme oxygenase-1 (HO-1) in their blood vessels.
- The research suggests that targeting Bach1 could be a promising new approach to treat atherosclerosis, as its absence led to less plaque buildup and lower markers of lipid damage in the DKO mice.
Article Synopsis
- Bach1 is a transcription factor that plays a role in managing stress responses and controlling protective factors like heme-oxygenase (HO)-1.
- In experiments with mice lacking the Bach1 gene, researchers found that removing Bach1 led to reduced left ventricular (LV) hypertrophy and remodeling after a heart stress test (TAC), as indicated by lower heart weight and gene expression levels associated with heart stress.
- The study suggests that the beneficial effects of deleting Bach1 are linked to increased levels of HO-1, proposing that targeting Bach1 could be a new way to protect the heart from damage in high-pressure conditions.
Role of osteoprotegerin in arterial calcification: development of new animal model.
Arterioscler Thromb Vasc Biol
September 2007
Objectives: Enhanced osteoclastogenesis, increased bone resorption, and osteoporosis have been reported in osteoprotegerin-deficient (OPG (-/-)) mice. OPG (-/-) mice available in Japan usually do not show vascular calcification. We have found that arterial calcification can be quickly induced by a simple procedure in OPG (-/-) mice.
View Article and Find Full Text PDFBackground: Angiotensin-converting enzyme inhibitors have been shown experimentally to prevent restenosis after balloon injury. We previously reported that quinapril reduced the 6-month restenosis (percent diameter stenosis >or=50%) rate after percutaneous coronary intervention (PCI). However, it was not established whether this favorable outcome was maintained for longer periods.
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