Publications by authors named "Shinji Misu"
Article Synopsis
- The study focuses on how nuclear structure and chromatin organization are restored after cell division, which is essential for proper genome function and development, but can be disrupted in cancer.
- During the exit from mitosis, a temporary formation of nuclear actin filaments (F-actin) occurs in daughter cells, aiding in nuclear expansion and chromatin decondensation.
- The research highlights the role of the actin-disassembling factor cofilin-1 in regulating these F-actin structures and their dynamics, emphasizing their importance in early developmental stages.
Actin is a highly abundant protein in eukaryotic cells and dynamically changes its polymerized states with the help of actin-binding proteins. Its critical function as a constituent of cytoskeleton has been well-documented. Growing evidence demonstrates that actin is also present in nuclei, referred to as nuclear actin, and is involved in a number of nuclear processes, including transcriptional regulation and chromatin remodeling.
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