Publications by authors named "Shinji Maeba"
Background Epidermolysis bullosa simplex (EBS) is a rare genodermatosis resulting from multiple gene mutations, including KRT5 and KRT14. The clinical expression of the mechanobullous skin fragility disease has not been fully explained by the genotype. Case Description An 11-day-old Japanese newborn infant was hospitalized because of herpetiform skin blistering on the feet, which expanded systemically after birth.
View Article and Find Full Text PDFBackground Herpes simplex virus (HSV) infection carries one of the poorest outcomes of neonatal liver failure (NLF). Neonates with disseminated HSV infection can develop hemophagocytic lymphohistiocytosis (HLH), and occasionally need orthotopic liver transplantation. Early interventions may be critical for the cure of NLF.
View Article and Find Full Text PDFBackground: Tau protein is a microtubule-associated protein that is present in axons. Elevated tau protein levels in cerebrospinal fluid or serum are associated with several central nervous system diseases and can indicate neuronal injury.
Objective: In the present study, we measured and then compared serum tau protein levels between infants with neonatal asphyxia and control subjects.
We investigated matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) levels in the cord blood of 29 premature infants who were <30 weeks gestation. One, 8, and 14 infants developed severe, moderate and mild bronchopulmonary dysplasia (BPD), respectively, and 6 did not. MMP-9 and TIMP-1 levels in the cord blood were determined by ELISA.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess how inhaled corticosteroids and high-frequency oscillatory ventilation affect preterm infants with chronic lung disease.
- Ten preterm infants with chronic lung disease were treated and their sputum samples were analyzed for various inflammatory cytokines before therapy and during the first four weeks.
- Results indicated that the levels of certain inflammatory markers significantly decreased after two weeks of corticosteroid therapy, suggesting reduced airway inflammation, with oscillatory ventilation showing quicker results compared to traditional methods.
Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) play important roles in the function of the blood-brain-barrier (BBB). We investigated the roles of MMP-9 and TIMP-1 in the pathogenesis of hypoxic-ischemic encephalopathy following perinatal asphyxia. Serum concentrations of MMP-9 and TIMP-1 were determined by ELISA in 12 neonates with perinatal asphyxia and 15 controls on the birth day and the next day.
View Article and Find Full Text PDFWe report male siblings with tibia-metacarpal type of chondrodysplasia punctata, which was diagnosed by radiographic findings and clinical appearances. This is the first report of siblings without maternal systemic lupus erythematosus or medications during both pregnancies.
View Article and Find Full Text PDFBackground: Subacute sclerosing panencephalitis (SSPE) is a rare progressive inflammatory disease characterized by the persistent infection of the brain by the measles virus. However, the immunological pathophysiology of SSPE is still unclear.
Methods: We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and soluble TNF receptor 1 (sTNFR1) in the serum and cerebrospinal fluid (CSF) of 23 patients with SSPE in Papua New Guinea (PNG), a country with a high incidence of SSPE, and Japanese controls by cytometric bead array or ELISA.
Article Synopsis
- The study explored the role of matrix metalloproteinases (MMP-9) and tissue inhibitors (TIMP-1) in acute disseminated encephalomyelitis (ADEM), a condition linked to inflammation and demyelination.
- During the acute stage of ADEM, serum levels of MMP-9 and TIMP-1 were found to be significantly higher compared to healthy controls, indicating a potential relationship with lesion activity as seen on MRI.
- The analysis suggested that while MMP-9 might contribute to lesion formation during the early phase of ADEM, TIMP-1 appears to regulate MMP-9's effects, underscoring their roles in the inflammatory mechanisms underlying the disease.
Effect of montelukast on nuclear factor kappaB activation and proinflammatory molecules.
Ann Allergy Asthma Immunol
June 2005
Background: Montelukast is known as a cysteinyl leukotriene 1 receptor antagonist. However, the action of montelukast in terms of nuclear factor KB (NF-kappaB) activation and the production of proinflammatory molecules is unknown.
Objective: To demonstrate the potential anti-inflammatory effect of montelukast.
Background: It is unclear whether or not the CSF cytokine profiles in viral meningitis differ with the kind of causative virus.
Methods: We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, and IL-10 in CSF during the acute stage in 15 children with mumps meningitis (MM), and 34 with echovirus type 30 meningitis (EM).
Results: The CSF IFN-gamma, IL-2, IL-6, and IL-10 levels were elevated in MM, and the CSF IFN-gamma, IL-2, and IL-6 levels were elevated in EM.