Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer.

Background: UbcH10 participates in proper metaphase to anaphase transition, and abrogation of UbcH10 results in the premature separation of sister chromatids. To assess the potential role of UbcH10 in colon cancer progression, we analyzed the clinicopathological relevance of UbcH10 in colon cancer.

Methods: We firstly screened the expression profile of UbcH10 in various types of cancer tissues as well as cell lines.