Publications by authors named "Shinil Raina"
Article Synopsis
- Astrocytes play crucial and underestimated roles in modulating neuronal circuits, particularly in the striatum, where they regulate dopamine transmission and interact closely with cholinergic interneurons (ChIs).
- The study reveals that striatal astrocytes rapidly excite ChIs and influence dopamine release through nicotinic acetylcholine receptors, operating on very fast timescales.
- A unique anatomical configuration is observed, where ChI somata are closely located to astrocyte somata, allowing for a dynamic interaction that regulates ChI excitability and extracellular calcium, thus impacting overall striatal circuit activity and dopamine signaling.
