Publications by authors named "Shinichiro Matsuyama"
Background: Serum levels of stratifin (SFN), a member of the 14-3-3 protein family, increase in patients with drug-induced lung injury associated with diffuse alveolar damage. Therefore, we hypothesised that SFN levels would be higher in those experiencing acute exacerbation of interstitial lung disease (AE-ILD). A secondary analysis was also planned to determine whether SFN levels could discriminate survival in those with AE.
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- - The study focuses on drug-induced interstitial lung disease (DILD), aiming to identify specific biomarkers to enhance clinical management and improve drug development outcomes.
- - Researchers discovered that serum levels of kynurenine and quinolinic acid were significantly higher in acute DILD patients compared to other lung disease patients and healthy controls, suggesting these could serve as effective diagnostic markers.
- - The findings indicate a potential relationship between increased kynurenine levels and inflammation, with experiments showing that certain inflammatory conditions can activate the kynurenine pathway in macrophages, contributing to elevated biomarker levels in DILD.
Article Synopsis
- The 2021 WHO classification of CNS tumors combines histopathology and molecular profiling to effectively differentiate between adult malignant brain tumors, particularly gliomas and primary CNS lymphomas (PCNSL).
- A new intraoperative integrated diagnostic (i-ID) system has been developed that enhances traditional frozen-section diagnosis with a qPCR-based genotyping assay, crucial for therapeutic decision-making.
- After testing the i-ID system on 101 patients, it showed high reliability, matching permanent diagnoses in nearly all cases, thus proving to be a valuable tool for accurate classification of adult malignant CNS tumors.
Among the various histopathological patterns of drug-induced interstitial lung disease (DILD), diffuse alveolar damage (DAD) is associated with poor prognosis. However, there is no reliable biomarker for its accurate diagnosis. Here, we show stratifin/14-3-3σ (SFN) as a biomarker candidate found in a proteomic analysis.
View Article and Find Full Text PDFThe prognosis of patients with severe cases of COVID-19 is poor; thus, biomarkers for earlier prediction of COVID-19 progression are vital. We measured levels of five lung injury-related biomarkers, SP-D, KL-6, presepsin, kallistatin and stratifin, in serum samples collected serially during hospitalization from 31 patients with mild/moderate or severe/critical COVID-19 pneumonia, and their predictive performances were compared. Like the previously reported presepsin, a new biomarker candidate, stratifin, was significantly elevated with the onset of severe or critical symptoms in COVID-19 patients and decreased with symptom improvement.
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