Publications by authors named "Shinichi Sasaki"

Article Synopsis
  • * Bacteriochlorophyll (BChl), essential for photosynthesis, was combined with TiCT MXene to create five composite photocatalysts aimed at enhancing hydrogen production under visible light.
  • * Among the variations, BChl-5 with a quaternary ammonium group achieved the highest hydrogen production rate of 51 μmol/h/g due to its strong self-aggregation and excellent electric charge transport with TiCT MXene.
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  • * He was initially treated with corticosteroids but developed refractory pneumothorax, which made managing the air leakage challenging.
  • * The treatment was successfully modified to include mepolizumab, an anti-interleukin-5 therapy, and an endobronchial Watanabe spigot, resulting in the resolution of the pneumothorax and no recurrence of EP post-treatment.
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The hopping charge transfer (CT) theory is used to explain the dynamics of traditional donor-acceptor (D-A) devices in organic solar cells (OSCs). But it is not applicable to the unconventional OSCs inspired by photosynthesis, referred to as Z-devices. In this study, we establish a universal heterojunction CT model in OSCs, based on the reported coherent CT in photosynthesis.

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Purpose: To determine whether there is a significant association between inflammatory cytokines in the tear fluid and the severity of Retinopathy of Prematurity (ROP).

Study Design: Retrospective cohort study.

Methods: The cytokine levels in tear fluids were determined in 34 eyes with ROP and 18 eyes without ROP.

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Aiming at the application to photodynamic therapy, natural bacteriochlorophyll-a was converted to chemically stable free-base derivatives possessing different kinds of hydrophilic C17-propionate residues. These semi-synthetic bacteriochlorins were found to have self-assembling ability in an aqueous environment and formed stable J-type aggregates in a cell culture medium containing 0.2% DMSO.

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  • The study explored the effectiveness of a treatment regimen called ABCP (atezolizumab, bevacizumab, carboplatin, and paclitaxel) for patients with EGFR-mutated non-small cell lung cancer (NSCLC) after failure of EGFR-tyrosine kinase inhibitors (TKIs).
  • Results from 60 patients showed a median progression-free survival (PFS) of 7.4 months and median overall survival (OS) of 23.1 months, with an overall response rate (ORR) of 55.9%.
  • However, the study did not reach its primary endpoint and indicated that PFS was notably shorter for patients with previous TKI treatment and those with brain or
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In this study, we fabricated a photodetector (PD) with two types of chlorophyll derivatives, namely, zinc methyl 3-devinyl-3-hydroxymethyl-pyropheophorbide-a (ZnChl) and methyl 13-deoxo-13-dicyanomethylene-pyropheophorbide-a (HChl'), via a two-step drop-coating process. In the absorption range of ZnChl/HChl' films, the maximum external quantum efficiency of ZnChl/HChl'-based devices reached 1363% at -8 V and 1345% at 2.5 V, exhibiting the photomultiplication (PM) phenomenon.

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Purpose: To estimate the roles of extracellular vesicles (EVs) in tears and to determine whether their profiles are associated with the type of ocular disease.

Study Design: Cross-sectional study.

Methods: Tear EVs were extracted from 14 healthy participants and from 21 patients with retinal diseases (age-related macular degeneration [AMD] or diabetic macular edema [DME]).

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Background: Interstitial lung disease/pneumonitis (ILD/pneumonitis) has been identified as a drug-related adverse event of special interest of trastuzumab deruxtecan (T-DXd), but there were a few reports of T-DXd-related ILD/pneumonitis in clinical practice.

Methods: Between May 25, 2020 (the launch of T-DXd in Japan) and February 24, 2022, there were 287 physician-reported potential ILD/pneumonitis cases from the Japanese post-marketing all-case surveillance. By February 27, 2022, an independent adjudication committee assessed 138 cases and adjudicated 130 cases as T-DXd-related ILD/pneumonitis.

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  • The study examines the categorization of relapsed small cell lung cancer (SCLC) as "sensitive" or "refractory" based on outdated cutoff values for time between chemotherapy and disease progression, which may not apply to modern treatments.
  • Researchers conducted a retrospective analysis involving patients treated before and after the approval of combination immunotherapy, identifying a new optimal cutoff value of 75 days for predicting overall survival.
  • Findings indicate that this 75-day cutoff provides a more accurate prognosis for patients with relapsed SCLC compared to traditional 60 or 90-day values, especially in the context of immunotherapy advancements.
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Hole-transporting layers (HTLs) play a crucial role in the performance of inverted, p-i-n perovskite solar cells (PSCs). Chlorophylls (Chls) are naturally abundant organic photoconductors on earth, with good charge carrier mobility and appropriate Fermi energy levels that make them promising candidates for use in photovoltaic devices. However, Chls films prepared using the solution method exhibit lower carrier mobility compared to other organic polymer films, which limits their application in PSCs.

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The high activity of water molecules results in a series of awful parasitic reaction, which seriously impede the development of aqueous zinc batteries. Herein, a new gel electrolyte with multiple molecular anchors is designed by employing natural biomaterials from chitosan and chlorophyll derivative. The gel electrolyte firmly anchors water molecules by ternary hydrogen bonding to reduce the activity of water molecules and inhibit hydrogen evolution reaction.

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Nintedanib reduces the decline in forced vital capacity and extends the time to the first acute exacerbation of interstitial lung disease (AE-ILD). However, the effect of additional nintedanib administration after AE-ILD onset is unknown. This study aimed to investigate the efficacy and safety of nintedanib administration after AE-ILD development.

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The organic electrolyte can resolve the hurdle of hydrogen evolution in aqueous electrolytes but suffers from sluggish electrochemical reaction kinetics due to a compromised mass transfer process. Herein, we introduce a chlorophyll, zinc methyl 3-devinyl-3-hydroxymethyl-pyropheophorbide- (Chl), as a multifunctional electrolyte additive for aprotic zinc batteries to address the related dynamic problems in organic electrolyte systems. The Chl exhibits multisite zincophilicity, which significantly reduces the nucleation potential, increases the nucleation sites, and induces uniform nucleation of Zn metal with a nucleation overpotential close to zero.

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Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death, and COPD exacerbation worsens the prognosis. Eosinophilic airway inflammation is a COPD phenotype that causes COPD exacerbation and is correlated with peripheral blood eosinophil count. We analyzed real-world data of COPD patients to assess the risk factors of COPD exacerbation focusing on blood eosinophils.

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Article Synopsis
  • The study aimed to identify inflammatory cytokines linked to pachychoroid neovasculopathy (PNV) by analyzing 75 PNV patients, 145 with age-related macular degeneration, and 150 normal subjects.
  • Results showed elevated levels of IL-1α, IL-1β, IL-2, IL-4, IL-10, and VEGF in PNV eyes compared to controls, with IL-4, IL-2, and IL-1α most strongly associated with pachyvessels.
  • IL-4 was particularly significant, correlating with choroidal thickness, vessel diameter, and polypoidal lesion formation, indicating its key role in PNV's clinical characteristics and vascular changes
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MXenes, a new family of 2D nanostructured materials, have been widely studied in the field of artificial photosynthesis due to their outstanding physicochemical properties. In this work, a series of 2,4-bis[4-(N,N-dibutylamino)phenyl] squaraine (SQ) derivatives with different number of hydroxyl groups were hybridized with TiCT MXene nanosheets, and the organic-inorganic hybrid photocatalysts were applied for water-splitting hydrogen evolution. The mass ratios of SQ@TiCT were optimized to 4 wt% for each SQ, and the best hydrogen evolution reaction (HER) rate of 28.

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In this study, cauda epididymal sperm were collected from Amur leopard cats with various causes of death as well as Tsushima leopard cats that underwent castration surgery, and sperm quality was compared with that in domestic cats. A sufficient number of sperm similar to those in domestic cats could be collected from the cauda epididymis of Amur leopard cats. However, in old leopard cats, no or very few cauda epididymal sperm were recovered, although there were no differences in sperm motility and sperm abnormality.

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Introduction: Cisplatin-based chemotherapy was established in the 1980s, and it has been improved by the development of a short hydration protocol in lung cancer therapy. However, cisplatin-based chemotherapy is still associated with renal toxicity. Because 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC) is known to be a mitochondrial activator and a heme oxygenase-1 (HO-1) inducer, 5-ALA with SFC is speculated to mitigate cisplatin-induced renal inflammation.

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In this article, we report the case of a patient with unresectable stage III squamous cell lung carcinoma who developed immune-related adverse events in the gastrointestinal tract following the administration of immune checkpoint inhibitors. The patient developed severe acute respiratory syndrome coronavirus 2 pneumonia and cytomegalovirus gastritis during immunosuppressive therapy for an immune-related adverse event. Cytomegalovirus infection was managed with the administration of ganciclovir.

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Hydrogen energy is an abundant, clean, sustainable and environmentally friendly renewable energy source. Therefore, the production of hydrogen by photocatalytically splitting water on semiconductors has been considered in recent years as a promising and sustainable strategy for converting solar energy into chemical energy to replace conventional energy sources and to solve the growing problem of environmental pollution and the global energy crisis. However, highly efficient solar-driven photocatalytic hydrogen production remains a huge challenge due to the poor visible light response of available photocatalytic materials and the low efficiency of separation and transfer of photogenerated electron-hole pairs.

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Objective Based on the increasing incidence of smell and taste dysfunction among coronavirus disease 2019 (COVID-19) patients, such issues have been considered an early symptom of infection. However, few studies have investigated the type of taste components that are most frequently affected in COVID-19 patients. This study investigated the difference in frequencies of the types of taste component disorders among hospitalized COVID-19 patients.

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