Publications by authors named "Shinichi Ban"

Article Synopsis
  • Esophageal cell tumors are uncommon, but a case study presented a 48-year-old woman with an elevated esophageal lesion and long-segment Barrett's esophagus identified through an endoscopy.
  • Endoscopic ultrasonography revealed a 15 mm tumor that extended from the lamina propria mucosa to the submucosa, which was later diagnosed as a granular cell tumor based on biopsy results showing specific cell characteristics.
  • This case marks the first documented instance of a granular cell tumor arising in the context of long-segment Barrett's esophagus, and the tumor was successfully removed via endoscopic submucosal dissection.
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  • Anastomosing hemangioma (AH) is a rare type of capillary hemangioma, often found in the genitourinary tract, and can be challenging to diagnose without tissue samples.
  • A 67-year-old woman with an asymptomatic retroperitoneal tumor, initially believed to be benign, underwent imaging that showed growth over 4 years, ultimately leading to surgical removal.
  • The tumor was pathologically confirmed as AH, which is very rare, representing only 1-3% of retroperitoneal tumors, and highlights the need for considering it in the diagnosis of heterogeneous masses in the para-aortic region.
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Testicular cancer, the most common cancer among young male adults, is associated with infertility. A 38-year-old male patient was admitted to Dokkyo Medical University Saitama Medical Center, Japan, with infertility associated with severe oligozoospermia. Scrotal ultrasonography revealed two distinct tumors in the left testis: A mass with abundant blood flow on the cranial side and a mass with poor blood flow on the caudal side.

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  • A 66-year-old woman with chronic anorexia was hospitalized after not eating for three days, showing severe anemia (hemoglobin of 3.3 g/dL) and a large gastric ulcer discovered via esophagogastroduodenoscopy.
  • A biopsy indicated irregular cell proliferation, raising concerns for possible liver-related issues, while CT scans did not show free air in the abdomen.
  • Despite conservative treatment, her condition worsened, leading to surgery where a total gastrectomy and partial hepatectomy were performed, revealing non-malignant findings, highlighting the rarity of gastric ulcers invading the liver in current medical contexts.
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Objective: To compare the risk of ovarian malignancy algorithm (ROMA) and Copenhagen Index (CPH-I) in their ability to distinguish epithelial ovarian cancer (EOC) and malignant ovarian tumors (MLOT) from benign ovarian tumors (BeOT) in Japanese women.

Methods: Patients with pathologically diagnosed ovarian tumors were included in this study. The study validated the diagnostic performance of ROMA and CPH-I.

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  • Advances in deep learning technology have led to the creation of a computer-assisted diagnostic tool for detecting lymph node metastasis in patients with gastric adenocarcinoma using whole-slide images.
  • A ResNet-152-based system was developed and tested against 70 LN images reviewed by pathologists to evaluate its effectiveness compared to traditional methods.
  • Results showed that while sensitivity for detecting micrometastases improved with algorithm assistance, it took longer to review, with the algorithm achieving a performance level that can enhance pathologists' diagnostic accuracy despite some limitations.
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The pathologic diagnosis of duodenal tumors is a developing field; however, its overview remains unclear. We describe a rare case of a duodenal gastric-type neoplasm in a 50-year-old woman. She visited her primary care doctor with complaints of upper abdominal pain, tarry stools, and shortness of breath on exertion.

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  • - Eosinophilic pancreatitis (EP) is a rare condition marked by a significant presence of eosinophils in the pancreas, which can lead to inflammation.
  • - A 40-year-old man who had ulcerative colitis for many years developed acute pancreatitis after starting treatment with golimumab, prompting further medical investigation.
  • - A biopsy revealed eosinophil infiltration in the pancreas, leading to a diagnosis of EP, for which he was treated with corticosteroids.
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A 70-year-old Japanese man with a submucosal gastric mass that continued to increase in size underwent endoscopic submucosal dissection using the pocket creation method. Histologically, some epithelial cell nuclei were enlarged, but there was little atypia overall and no sign of malignancy, suggesting a diagnosis of submucosal heterotopic gastric gland (SHGG). SHGG that enlarges over time has been associated with gastric cancer, but a preoperative diagnosis is difficult.

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  • - This study investigates how the expression of gastrin receptors (GR) in gastric cells relates to both the presence of fundic gland polyps (FGPs) and the effects of proton pump inhibitors (PPIs) on gastric mucosa.
  • - Key findings show that gastrin receptor expression in parietal cells is influenced by PPI use, indicating that changes in cell compartmentalization could reflect certain pathological conditions in the stomach lining.
  • - The research concludes that the distribution of GR expression could help assess the health of the gastric mucosa, especially in patients with a history of PPI medication and those with FGPs.
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Background: Anorexia nervosa not only results in severe malnutrition but also carries a high risk of sudden death. Although fatal arrhythmias are the most common cause of sudden death, it is often unclear what exactly causes them. To the best of our knowledge, there have been no reports of cerebellar tonsillar herniations in patients with anorexia nervosa.

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Small cell lung carcinoma (SCLC) and pulmonary large cell neuroendocrine carcinoma (LCNEC) are both classified as lung neuroendocrine carcinoma (NEC). It has recently been reported that the special AT-rich sequence-binding protein 2 (STAB2), known as a colorectal cancer marker, is also expressed in NECs occurring in various organs including the lung. However, few studies have examined any differences of SATB2 immunopositivity between SCLC and LCNEC.

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Objectives: To evaluate whether the long-term usage of mirabegron, which was reported to have potential side effects on male reproductive organs in animal studies, was harmful to spermatogenesis in human testis.

Methods: Thirty consecutive patients with spinal cord injury (20-48 years old) who performed clean intermittent catheterization were involved in this study. Ten patients were treated with mirabegron (50 mg/d) for more than 2 years and refrained from using an antimuscarinic agent due to the side effects of constipation and dry mouth.

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Hepatic artery aneurysm has been considered as a rare, life-threatening disease. In this study, we report on a patient requiring surgical treatment for a giant hepatic artery aneurysm by aneurysmectomy without revascularization. A 70-year-old woman who complained of epigastric pain was referred to our hospital.

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The risk of a gonadal tumor is high in testicular disorder of sexual development (DSD) with the Y chromosome, but cases of DSD without the Y chromosome are extremely rare. We reported a gonadal tumor in a phenotypically male individual with 46, XX testicular DSD. A testicular tumor was incidentally found in a 32-year-old phenotypic male who was presented to the hospital with male infertility.

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Article Synopsis
  • - The article discusses gastric epithelial neoplasms that show chief cell differentiation, specifically focusing on a type called "gastric adenocarcinoma of fundic gland mucosa type" (GA-FGM), which may be more aggressive than others.
  • - A five-year case study is presented where a tumor diagnosed as GA-FGM was monitored, revealing minimal changes in appearance but significant histological progression, indicating deeper tissue involvement.
  • - The study suggests that the presence of other oxyntic gland neoplasms appearing either at the same time or later may point to a shared underlying cause for these types of gastric lesions.
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Background: Fibrosis surrounding cancer cells has been shown to affect cancer cell metastatic behavior. The present study aimed to explore the utility of myxoid stroma as a predictive factor for postoperative relapse in patients with stage II colon cancer.

Methods: The present study retrospectively investigated 169 patients who underwent curative surgical resection of stage II colon cancer.

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We encountered a case of wall thickening of the bile duct in a 69-year-old man. endoscopic retrograde cholangiopancreatography (ERCP) was performed for detailed examination. When an area considered to be the healthy bile duct was examined by peroral cholangioscopes (POCS) (SPYGlass DS), the vascular network was observed.

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Purpose: Pancreatic/gastrointestinal tract neuroendocrine neoplasm (NEN) is divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) according to the grade of malignancy, and differences are seen in clinical prognosis. NET, and rectal NET in particular, is often treated endoscopically. Endoscopic mucosal resection (EMR) was previously the main intervention for rectal NET, but EMR with a ligation device (EMR-L) and endoscopic submucosal dissection (ESD) are now also used.

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Pyoderma gangrenosum (PG) is a skin disease characterized by an unknown neutrophilic infiltration in dermis and a nonbacterial destructive ulcer. Post-operative PG is an extremely rare type that occurs around surgical sites during the immediate post-operative period. It is usually diagnosed as surgical site infection at the time of presentation.

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Esophagogastroduodenoscopy of a 45-year-old woman revealed a submucosal tumor in the gastric antrum. Endoscopic submucosal dissection of the tumor was performed. The histological findings revealed a fibromyxomatous tumor composed of myofibroblastic cells with no evidence of malignancy.

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