Publications by authors named "Shingo Tojo"
Article Synopsis
- TLR7 can recognize both harmful and harmless RNA, and its overactivation is linked to autoimmune diseases like systemic lupus erythematosus (SLE).
- Researchers created specific antagonists to TLR7 that show promise as treatments for SLE by protecting mice from serious autoimmune reactions.
- Using advanced imaging techniques, they uncovered how these antagonists fit into TLR7, revealing its structural changes that help understand how to effectively target this receptor for therapy.
Indoleamine 2,3-dioxygenase 1 (IDO1) is considered as a promising target for the treatment of several diseases, including neurological disorders and cancer. We report here the crystal structures of two IDO1/IDO1 inhibitor complexes, one of which shows that Amg-1 is directly bound to the heme iron of IDO1 with a clear induced fit. We also describe the identification and preliminary optimization of imidazothiazole derivatives as novel IDO1 inhibitors.
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