Publications by authors named "Shingo Koyama"

Background We aimed to investigate the association between protein intake and quadriceps quantity and quality on the paretic and non-paretic sides during rehabilitation in people with subacute stroke. Method Eighty-six people with stroke were recruited from a rehabilitation ward. We measured quadriceps muscle quantity and quality on the paretic and non-paretic sides using ultrasonography at admission and after 4weeks.

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Background/objectives: Our aim was to compare the complication rates of different embolization materials (absolute ethanol and gelatin sponges) used for combined transarterial embolization (TAE) and to investigate the impact of tumor size on operative time and cryoneedle use during percutaneous cryoablation (PCA).

Methods: We treated 27 patients (9 women and 18 men; mean age, 74 years) with 28 early-stage (T1a) renal cell carcinoma (RCC) lesions using combined TAE and PCA between September 2018 and January 2021. During TAE, 15 lesions in 14 patients were embolized using mixed absolute ethanol and iodized oil.

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  • The study evaluates the effectiveness of dual-energy computed tomography (DECT) for detecting pancreatic cancer by comparing low-KeV and conventional CT images during different phases of imaging.
  • Twenty-five patients with pancreatic cancer were analyzed, producing images at 50 KeV and 70 KeV to assess differences in tumor-to-pancreas contrast.
  • Results showed that low-KeV images had significantly better contrast in the pancreatic parenchymal phase, especially for small tumors, indicating DECT's potential for improving early pancreatic cancer detection.
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Follicular lymphoma is a common hematologic malignancy; however, it is less common among all malignant diseases and is difficult to suspect in advance due to the lack of specific clinical findings. Here, we report a case in which a late recurrence of corpus cancer was first suspected and finally diagnosed as follicular lymphoma. A 67-year-old female presented to our department with enlarged pelvic lymph nodes.

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  • The study aimed to investigate how the frequency and duration of physical therapy (PT) impact hospitalization-associated disability (HAD) in elderly patients with heart failure (HF).
  • It involved analyzing data from hospitalized patients aged 65 and older who received PT, categorizing them into three groups based on their PT frequency and duration.
  • Results indicated that patients with lower frequency and shorter duration of PT faced a significantly higher risk of developing HAD, suggesting that more intensive therapy could help mitigate this risk.
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Purpose: The effect of increased physical activity duration on functional recovery in older inpatients in subacute settings is not well established. This study aimed to investigate the relationship between physical activity and functional recovery in older patients receiving post-acute and subacute care.

Methods: We analyzed cohort data of hospitalized older patients (age ≥ 65 years) in the post-acute rehabilitation units.

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Objectives: We aimed to determine the association between changes in nutritional status and the activities of daily living (ADL) at discharge, considering frailty status of older patients with heart failure (HF).

Methods: This study included 491 older inpatients with HF categorized into the following groups based on their clinical frailty scale (CFS) scores: low, intermediate, and high. Changes in nutritional status were assessed using the Controlling Nutritional Status score at admission and discharge.

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Introduction: Skeletal muscle function is an important prognostically relevant indicator in patients with acute leukemia (AL), but skeletal dysfunction during chemotherapy is not well understood. This study aimed to investigate the factors that influence changes in skeletal muscle function from before the start of chemotherapy to before allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods: This was a retrospective cohort study that included 90 patients with AL who underwent chemotherapy before transplantation to perform allo-HSCT (men, 67.

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  • - The study examined nailfold capillary parameters in community-dwelling seniors over 60 with hypertension and low exercise levels to see how microcirculation relates to health indicators.
  • - Conducted at Tsukuba University of Technology in Japan, the pilot trial involved observing microcirculation before and after a 1-minute arm-curl exercise, revealing significant increases in capillary flow and density post-exercise.
  • - Results showed that even short bouts of exercise can enhance capillary function in elderly individuals, establishing connections between microvascular health and factors like body fat, physical activity, and bone density.
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Background: Refractory ascites affects the prognosis and quality of life in patients with liver cirrhosis. Peritoneovenous shunt (PVS) is a treatment procedure of palliative interventional radiology for refractory ascites. Although it is reportedly associated with serious complications (e.

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Background: Exercise therapy is the key to preventing admission of patients with type 2 diabetes mellitus (T2DM). However, a few studies have examined the effects of exercise therapy on patients with T2DM undergoing inpatient diabetes self-management education and support (IDSMES).

Objective: This study investigated whether exercise therapy influenced the incidence of admission after discharge in patients with T2DM undergoing IDSMES.

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Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic neurological syndrome that is rarely accompanied by seropositivity with a combination of multiple antibodies. We herein report a 50-year-old man with PCD accompanied by small-cell lung cancer (SCLC). This patient was seropositive for anti-glutamic acid decarboxylase 65, anti-SRY-related HMG-box gene 1 and anti-voltage-gated calcium channel antibodies.

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Aim: We assessed care receivers' sharing ratios of household tasks before they required care and investigated their relationship with caregiver burden.

Methods: A cross-sectional, online survey was completed by 272 spousal caregivers in Japan. Caregiver burden was assessed using the Zarit Burden Interview.

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Background: Muscle strength and nutritional status are associated with length of hospital stay (LOHS) in older patients with heart failure (HF).

Objectives: The purpose of the study was to examine the association of the combination of muscle strength and nutritional status on LOHS in older patients with HF.

Methods: This retrospective cohort study included 414 older inpatients with HF (men, 57.

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  • The patient had anti-ganglioside antibodies, specifically anti-GQ1b IgG and anti-GT1a IgG, leading to a range of neurological symptoms including issues with eye movement and facial nerves.
  • Initial treatment with intravenous immunoglobulin improved some symptoms but worsened facial nerve issues and did not clear the MRI findings.
  • Switching to high-dose methylprednisolone therapy eventually improved both facial nerve problems and reduced the MRI enhancements of the cranial nerves, marking a significant case in understanding such antibody-related conditions.
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Introduction: Poor skeletal muscle function is relatively high in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), leading to various negative health outcomes. This study aimed to investigate the relationship between the quantity and quality of skeletal muscle before transplantation and the short-to long-term survival after transplantation in patients undergoing allo-HSCT.

Methods: This retrospective cohort study included 156 patients undergoing allo-HSCT (men, 67.

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Pelvic fractures are common in cases of blunt trauma, which is strongly associated with mortality. Transcatheter arterial embolization is a fundamental treatment strategy for fatal arterial injuries caused by blunt pelvic trauma. However, vascular injuries due to blunt pelvic trauma can show various imaging findings other than arterial hemorrhage.

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  • Variants in the valosin-containing protein (VCP) gene are linked to inclusion body myopathy, Paget disease of the bone, and frontotemporal dementia (FTD); however, the p.Asp395Gly variant specifically leads to familial FTD with tauopathy.
  • The case study details a 62-year-old man who displayed symptoms of FTD, including depression and self-centered behavior, with imaging confirming frontal lobe atrophy and functional issues.
  • Genetic testing revealed the p.Asp395Gly variant in the patient's VCP gene, marking a case of pure FTD without muscle or bone disease, suggesting a distinct pathophysiological pathway.
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  • - The study explored how idiopathic normal pressure hydrocephalus (iNPH) develops over time in a community cohort, focusing on participants initially studied in 2000 and re-evaluated in 2016 when they were around 86 years old.
  • - Out of 104 participants examined, the prevalence of iNPH was found to be 7.7%, with 11 patients diagnosed over 16 years; notable findings included that a significant percentage of those with asymptomatic ventriculomegaly (AVIM) progressed to iNPH.
  • - The research concluded that iNPH is common in older adults and can develop through both asymptomatic ventriculomegaly and enlarged subarachnoid spaces,
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Introduction: Dysphagia has received much attention as a factor that affects caregiver burden. However, few studies have examined how its severity can affect caregiver burden. This study aimed to examine the effect of dysphagia severity on caregiver burden.

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Background: No previous study has examined the effect of dual-task training using changes in regional cerebral blood flow (rCBF) using single-photon emission computed tomography (SPECT) as an outcome.

Objective: This study aimed to examine the effects of simultaneous dual-task training of exercise and cognitive tasks on rCBF using SPECT in older adults with amnestic mild cognitive impairment (aMCI).

Methods: In this non-randomized control trial, 40 older adults with aMCI participated from May 2016 to April 2018.

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  • The study aimed to examine how lower muscle quality and quantity affect the risk of falls and fall-related fractures in older adults over three years.
  • Researchers analyzed data from 773 community-dwelling adults aged 65 and older, assessing their muscle health at the beginning of the study.
  • Results indicated that participants with lower muscle quality and quantity had a significantly higher risk of falling, though no major differences in fall-related fractures were found among different muscle health groups.
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Background: Cerebrotendinous xanthomatosis (CTX) is an autosomal-recessive lipid storage disorder caused by mutations in the CYP27A1 gene encoding the key enzyme in the bile acid synthesis, sterol 27-hydroxylase. Here, we report two Japanese CTX siblings with a novel compound heterozygous CYP27A1 mutation, showing different clinical phenotypes and responses to chenodeoxycholic acid (CDCA) therapy.

Case Presentation: The proband, a 32-year-old man, who had chronic diarrhea, bilateral cataracts, and xanthomas, demonstrated progressive neurological manifestations including ataxia, and spastic paraplegia during a 5-year follow-up period despite normalization of serum cholestanol after initiation of CDCA treatment.

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Objectives: This study examined the social factors affecting the frequency of going out, and social isolation related to the frequency of daily conversation, stratified by gender.

Method: The participants comprised 1,016 community-dwelling older Japanese adults, who were categorized into four groups: those who are (1) not isolated socially and go out every day, (2) not isolated socially and do not go out every day, (3) socially isolated and go out every day, and (4) socially isolated and do not go out every day. We performed a logistic regression analysis to assess the relationship between the frequency of daily conversation and the four groups.

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