Elevated urinary biopyrrin excretion and oxidative bilirubin metabolism during 24-hour ultramarathon running.

The oxidative metabolite of bilirubin, biopyrrin, is considered a useful candidate marker of oxidative stress in vivo. The present study examines whether urinary biopyrrin excretion is elevated and how general laboratory parameters are changed by long-duration running such as that involved in ultramarathons. Fifteen volunteer runners (12 males and 3 females; aged 44 +/- 9 years; means +/- SD) provided written informed consent to participate in this study.

Hypertension management in diabetic patients: prescribing trends from 1999 to 2005 in three Japanese university hospitals.

Purpose: In hypertensive patients with diabetes, antihypertensive therapy is important in reducing the risk of macro- and microvascular complications. In contrast to the guidelines issued by the American Diabetes Association (ADA) in and after 2002, the guidelines issued by the Japanese Society of Hypertension (JSH) in 2000 and 2004 maintained the traditional view that beta-blockers and thiazides should be rated as second-line drugs. However, both sets of guidelines recommended angiotensin converting enzyme inhibitors and angiotensin II receptor blockers (ARBs) as first-line agents for such patients.

[Clinical biochemical evaluation of central fatigue with 24-hour continuous exercise].

Objective: The present study was conducted to clarify the effects of ultra-marathon (ultra long-term aerobic exercise in which people run long distances) on the brain; examine the issue of central fatigue; verify the serotonin hypothesis of exercise-induced brain fatigue, and ascertain relationships between central fatigue and oxidative stress.

Methods: Subjects consisted of 15 individuals (12 men, 3 women) who ran continuously for 24 h. Mean age was 44 +/- 9 years (range, 31 approximately 64 years).