Publications by authors named "Shing S Chan"
Article Synopsis
- Heterochromatin protein 1 (HP1) is crucial for gene silencing but can also activate gene expression under certain conditions, particularly in skeletal muscle cells.
- Research showed that HP1α, one of the three HP1 isoforms, is essential for the expression of muscle-specific genes during muscle cell differentiation.
- Depletion of HP1α not only reduces the transcription of these genes but paradoxically increases a specific histone modification (H3K9me3), revealing a novel role for HP1α in gene activation through its interaction with the demethylase JHDM3A.
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury.
J Mol Cell Cardiol
November 2008
Ischemia/reperfusion (I/R) injury to the heart is accompanied by the upregulation and posttranslational modification of a number of proteins normally involved in regulating cell cycle progression. Two such proteins, cyclin-dependent kinase-2 (Cdk2) and its downstream target, the retinoblastoma gene product (Rb), also play a critical role in the control of apoptosis. Myocardial ischemia activates Cdk2, resulting in the phosphorylation and inactivation of Rb.
View Article and Find Full Text PDFNormally, cell cycle progression is tightly coupled to the accumulation of cell mass; however, the mechanisms whereby proliferation and cell growth are linked are poorly understood. We have identified cyclin (Cyc)D2, a G(1) cyclin implicated in mediating S phase entry, as a potential regulator of hypertrophic growth in adult post mitotic myocardium. To examine the role of CycD2 and its downstream targets, we subjected CycD2-null mice to mechanical stress.
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