Blood pressure and hormonal responses to aerobic exercise.

Twelve patients with essential hypertension (WHO stages I-II) were subjected to mild aerobic exercise for 10 to 20 weeks. The time course of changes in the resting blood pressure and multiple hormonal responses (plasma catecholamines, prostaglandin E, renin-angiotensin system, kallikrein-bradykinin system) were monitored. Depressor response of both systolic and diastolic pressures was seen, and after 5 weeks of exercise blood pressure stabilized at a significantly lower level.

Relationship between myoelectric signals and blood lactate during incremental forearm exercise.

Five men performed incremental forearm exercise by using a modified hand grip dynamometer while external loads (1 Kg metal plate) were added at each succeeding minute until volitional exhaustion occurred. Myo-electric signals were recorded from the belly of the flexor carpi radialis-palmaris longus. By the use of an LSI-11/23 minicomputer, the digitized data were processed for integrated EMG (IEMG) and mean power frequency (MPF) by means of 512 point fast Fourier transform.

Changes in reciprocal Ia inhibition during voluntary contraction in man.

Reciprocal Ia inhibition from ankle flexors to extensors was studied during voluntary tonic isometric dorsiflexion and plantar flexion in five normal subjects. The Ia inhibition was examined as the short-latency suppression of the soleus H-reflexes by stimulation of the low-threshold afferents in the common peroneal nerve (Mizuno et al. 1971).

Changes in reciprocal Ia inhibition from wrist extensors to wrist flexors during voluntary movement in man.

Transmission in the Ia inhibitory pathway from wrist extensor muscles onto flexor MNs was studied at various times after the onset of voluntary wrist extension or flexion. At the very onset of wrist movements Ia inhibition was not changed, as compared to at rest, whereas later it progressively increased during wrist extension and decreased during wrist flexion. These results are discussed in relation to the different inputs converging onto Ia interneurones and it is suggested that their inhibition by Renshaw cells might be responsible for the results found at the onset of contraction.

[Recovery process of auditory perceptual disorders in a child with word deafness].

The patient was a right-handed boy. Pregnancy and delivery were normal. There were no neonatal complications.

Intravesical chemotherapy of urinary bladder tumor in rabbit by ferromagnetic mitomycin C.

Considering the necessity of selective toxicity in cancer chemotherapy, an advantageous means of controlling the anticancer agent in the urinary bladder was facilitated by microencapsulation of the drug and ferrite particles. Pharmacokinetic analysis of intravesical instillation chemotherapy in rabbits proved that magnetic control of ferromagnetic microencapsulated mitomycin C (MMC) remarkably enhanced MMC absorption into the urinary bladder wall. Moreover, malignant bladder tumors in rabbits were successfully treated with this method.

[A case of hysterical deafness].

A forty years old woman with hysterical deafness is reported. Chief complaints were bilateral hearing loss. Nothing particular was found in her past and family history.

[Arterial infusion of microencapsulated mitomycin C for the treatment of locally recurrent carcinoma of the pelvic cavity].

Ethylcellulose microcapsules of mitomycin C (MMC) were prepared. The potential therapeutic effects of intra-arterial infusion of the microencapsulated anti-cancer drugs were considered to be a function of microembolization and prolonged the drug action, that is, chemoembolization. A total of 19 patients with locally recurrent carcinoma of the pelvic cavity was subjected to transcatheter arterial chemoembolization with microencapsulated MMC.

[Indication and effect of intra-arterial injection of mitomycin microcapsules in the treatment of kidney cancer].

Though a variety of treatments have been employed as an adjuvant for renal cell carcinoma, none of them has proved to be significantly effective, suggesting the difficulty in the treatment of this disease. The transcatheter arterial chemoembolization utilizing mitomycin C microcapsules developed by us was applied to renal cell carcinoma with an attempt at enhancing the chemotherapy and embolization. The early results indicate that this mode of treatment facilitates radical nephrectomy due to its marked antineoplastic effects and provides a favourable prognosis in locally advanced renal cancer.