Establishing the Cut-Off Values of 17-Hydroxyprogesterone for Diagnosing Congenital Adrenal Hyperplasia: A Prospective Observational Study in a Tertiary Care Hospital.

Introduction Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder primarily caused by 21-hydroxylase enzyme deficiency, impairing cortisol synthesis and resulting in elevated androgen levels. CAH presents in two classical forms: salt-wasting (SW) and simple virilizing (SV). Although CAH is rare in India, regional variations and the absence of a national newborn screening (NBS) program pose significant challenges to accurate diagnosis.

Correlating symptom severity index, clinical diagnostic criteria of CTS-6 and timed Phalen's test in clinical evaluation of carpal tunnel syndrome.

Background: Carpal Tunnel Syndrome (CTS) poses significant diagnostic challenges, especially in resource-limited settings. Reliable tools such as the 6-item Symptom Severity Index, Timed Phalen's Test (TPT) and CTS-6 are promising but under investigated. Correlation between these tools and symptom severity remains underexplored.

New 7-hydroxycoumarin acetamide derivatives as human carbonic anhydrase IX and XII inhibitors: Design, synthesis, biological evaluation and molecular docking studies.

Carbonic anhydrases (CAs) are crucial in regulating various physiological processes in the body. The overexpression of isoforms human carbonic anhydrases (hCA) IX and hCA XII is linked to tumour progression. The selective inhibition of CA IX and CA XII isoforms can result in the development of better cancer treatment strategies.

Relationship between smoking and pulmonary tuberculosis based on positive sputum smears.

Introduction: Smoking and tuberculosis are the two major, global health problems. Not only active smokers but also passive smokers are at risk of becoming infected with tuberculosis. Through many mechanisms, smoking decreases immunity and predisposes to numerous infections.

Grading of Knee Osteoarthritis Based on Kellgren-Lawrence Classification and Finding an Association Between Radiographic Features and Pain: A Cross-Sectional Study at a Tertiary Health Care Hospital.

: Osteoarthritis leads to painful joints, disability, restriction of ambulation, and reduces the person's ability to perform activities of daily living. Pain is one of the major symptoms of osteoarthritis. Some patients presented with severe pain while some with severe deformity.

Functional Outcome of Intertrochanteric Fractures of the Femur Treated With Standard Surgical Modalities.

Introduction: Among the most prevalent injuries among the elderly with trivial trauma are trochanteric fractures. Osteoporosis and female sex are additional risk factors. The patient's age, the fracture, their overall health, the amount of time between the fracture and treatment, the effectiveness of the treatment, any concurrent medical care, and the stability of the fixation all affect how well the patient responds to treatment.

Simplistic approach to formulate an ionophore-based membrane and its study for nitrite ion sensing.

A polymeric membrane based on a ,'-bis(salicylidene)ethylenediaminocobalt(ii) complex as a cobalt ionophore (CI) was fabricated and optimized for nitrite ion sensing application. The membrane contained CI, 2-nitrophenyl octyl ether (2-NPOE) as a plasticizer and hexadecyl trimethyl ammonium bromide (HTAB) as a cationic additive in a polyvinyl chloride (PVC) matrix. The Nernstian slope (-0.

Clinical Insights Into Lower Incisor Extraction for Orthodontic Treatment: A Case Report.

Extracting a single lower front tooth can be an appropriate treatment for class I malocclusions when the alignment of the upper teeth is normal and there is an adequate overlap of the teeth. This approach is particularly effective in cases of significant crowding in the lower front teeth, especially when the space deficiency exceeds 4-5 mm and the combined width of the lower front teeth surpasses 83 mm. It is also a viable option for malocclusions resulting from discrepancies in tooth size, such as narrower upper front teeth or larger lower front teeth.

Comparative Evaluation and Correlation of Hyoid Bone Position, Airway Dimension, and Psychological Status in Class II Vertical and Horizontal Malocclusion Cases With Temporomandibular Disorder Compared to Class I Non-Temporomandibular Disorder Cases.

Introduction Temporomandibular disorder (TMD) involves discomfort and impaired function in the masticatory muscles and temporomandibular joint (TMJ), with a multifaceted etiology that includes biomechanical, neuromuscular, psychological, and biological factors. This research aims to assess and correlate the hyoid bone position, airway dimensions, and psychological status in class II Hz (horizontal) and Vt (vertical) malocclusion cases with TMD in contrast to non-TMD class I cases. Methodology This research was carried out at the Orthodontics Department, Sharad Pawar Dental College and Hospital, Sawangi, with consent obtained from the ethical committee.

SimCapture app video performance assessment versus real-time instructor-based performance evaluation of undergraduates in neonatal resuscitation-an agreement study.

Undergraduates are trained in the basic neonatal resuscitation programme (NRP) and evaluated for skill acquisition by NRP performance evaluation test (PET). Video use improves the validity of assessment when video-information adequacy, intrusiveness to students, and educational purpose are adequately balanced. We evaluated whether there was a difference between instructor's real-time assessment and video-based assessment done by another independent assessor using videos recorded via the SimCapture application.

Minimally Invasive Access Cavity Designs: A Review.

Access cavity preparation, chemo-mechanical preparation, and obturation make up the majority of the endodontic triad. Every action should be carefully observed by the clinician. In the last two decades, endodontics has seen advancements in both technology and materials.

High Dependency Units (HDUs) in Pediatrics: Need of the Hour in Resource-Limited Settings.

Background Critically ill children, being vulnerable and having higher mortality as compared to adults, require specialized intensive care. However, the focus of critical care remains on adults, especially in resource-limited countries. Limited beds in the pediatric intensive care unit (PICU) along with the limitation of infrastructure and staff add to the challenge in pediatric critical care.

Early Intervention in Class II Division 1 Malocclusion Using an Activator Appliance: A Case Study.

The field of orthodontics has traditionally been regarded as the primary specialty within dentistry. As per Dr. Tweed's recommendation, historical treatment approaches often entailed the extraction of four premolar teeth.

Synthesis, Crystal and Electronic Structures, and Magnetic and Electrical Transport Properties of Bismuthides NdZnBi and (LaRE)ZnBi (RE = Pr or Nd).

Bismuth is a good constituent element for many quantum materials due to its large atomic number, 6s6p orbitals, and strong spin-orbital coupling. In this work, three new bismuthides, NdZnBi, (LaPr)ZnBi, and (LaNd)ZnBi, were grown by a metal flux method, and their crystal structures were accurately determined by single-crystal X-ray diffraction. These new bismuthides belong to the RE-T-Pn (RE = La-Lu, T = Mn, Fe, Co, Ni, or Zn, and Pn = P, As, Sb, or Bi) family, are isostructural, and crystallize in the HfCuSi structure type.

Exposure to Valsartan Products Containing Nitrosamine Impurities in the United States, Canada, and Denmark.

Background: Following the mass recall of valsartan products with nitrosamine impurities in July 2018, the number of patients exposed to these products, the duration of exposure, and the potential for cancer remains unknown. Therefore, we assessed the extent and duration of use of valsartan products with a nitrosamine impurity in the United States, Canada, and Denmark.

Methods: We conducted a retrospective cohort study using administrative healthcare data from the US FDA Sentinel System, four Canadian provinces that contribute to the Canadian Network for Observational Drug Effect Studies (CNODES), and the Danish National Prescription Registry.

Nanostructured electroless Ni deposited SnO for solar hydrogen production.

Herein, Ni-decorated SnO (Ni@SnO) nanostructures have been synthesized using SnO as a matrix a simple electroless deposition method for the generation of hydrogen, a potent near-future fuel. XRD analysis confirmed the generation of rutile SnO in Ni@SnO. FESEM and FETEM imaging exhibited the formation of SnO nanoparticles with a size of 10-50 nm, which are deposited with Ni nanoparticles (5-7 nm) and intermittent films (thickness 1-2 nm).

Survey of Basic Neonatal Resuscitation Program (NRP) Participants in India.

Objective: To assess the effectiveness of the Basic Neonatal Resuscitation Program (NRP) course and to evaluate the perceived utility of the skills acquired during the course.

Methods: This cross-sectional survey aimed to assess the perceptions of participants who attended the Basic NRP course, comprising online video modules and offline workshops, across India. Data were collected between October 2023 and November 2023 for the courses held from May 2022 to April 2023, using a semi-structured questionnaire distributed electronically or via telecommunication.

A Literature Review of the Integration of Ancient Indian Mythology in Clinical Medicine: A Holistic Approach to Health and Healing.

The fusion of mythology and ancient Indian medicine, particularly Ayurveda, is a fascinating synthesis of cultural heritage and scientific endeavor. Ayurveda encompasses a wide range of practices, including pharmacology, anatomy, physiology, surgery, and obstetrics, and integrates the rich tapestry of Hindu mythology, providing a comprehensive understanding of health and disease. The inclusion of mythological figures and narratives in the discourse of ancient Indian medicine offers a unique perspective on the integration of spiritual and empirical knowledge, highlighting the role of mythology in shaping the foundational principles of clinical medicine.

Nanoprimers in sustainable seed treatment: Molecular insights into abiotic-biotic stress tolerance mechanisms for enhancing germination and improved crop productivity.

Abiotic and biotic stresses during seed germination are typically managed with conventional agrochemicals, known to harm the environment and reduce crop yields. Seeking sustainable alternatives, nanotechnology-based agrochemicals leverage unique physical and chemical properties to boost seed health and alleviate stress during germination. Nanoprimers in seed priming treatment are advanced nanoscale materials designed to enhance seed germination, growth, and stress tolerance by delivering bioactive compounds and nutrients directly to seeds.

Addressing Missing Permanent Premolars With Retained Deciduous Teeth: Orthodontic Solutions and Outcomes.

This case report presents an orthodontic treatment approach involving retained deciduous teeth. The patient presented with a Class I malocclusion and buccal crossbite. Despite the presence of retained deciduous teeth, a non-extraction treatment plan was devised to address the malocclusion and achieve optimal dental alignment.

The Co-occurrence of Cleft and Clubfoot: A Case Report on a Rare Medical Condition.

Cleft lip and palate (CLP) are complex deformities in craniofacial development that can range from isolated to syndromic presentations. This case presentation emphasizes the identification and early management of syndromic associations in patients with CLP. The report presents a unique case of a one-month-old female patient with complete unilateral CLP and clubfoot.

The Future of Orthodontics: Deep Learning Technologies.

Deep learning has emerged as a revolutionary technical advancement in modern orthodontics, offering novel methods for diagnosis, treatment planning, and outcome prediction. Over the past 25 years, the field of dentistry has widely adopted information technology (IT), resulting in several benefits, including decreased expenses, increased efficiency, decreased need for human expertise, and reduced errors. The transition from preset rules to learning from real-world examples, particularly machine learning (ML) and artificial intelligence (AI), has greatly benefited the organization, analysis, and storage of medical data.

Pregnancy Outcomes and Maternal Periodontal Diseases: The Unexplored Connection.

In the early 20th century, numerous in-vitro studies, animal studies, epidemiological studies, and human trials have attempted to demonstrate the interrelationship between pregnancy outcomes and maternal periodontal disease. This review aims to shed light on the unexplored connections between pregnancy outcomes and maternal periodontal diseases. A literature search was conducted using electronic databases such as PubMed, Scopus, Google Scholar, Web of Science, and Embase.