Publications by authors named "Shin-ichiro Horigane"
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Synopsis of recent research by authors named "Shin-ichiro Horigane"
- Recent research by Shin-Ichiro Horigane focuses on the role of calcium signaling in neurodevelopment and neurological disorders, particularly using advanced calcium imaging techniques on immature cortical neurons and genetic models to understand CaMKIIα activity and its mutations associated with intellectual disabilities.
- Horigane's work includes the development of novel genetically encoded calcium indicators, such as G-CaMP9a, to enhance neuronal imaging capabilities, allowing for detailed studies on calcium dynamics in specific neuronal populations and elucidating mechanisms behind emotional behaviors and developmental disorders.
- His findings contribute valuable insights into the genetic and molecular underpinnings of psychiatric conditions like schizophrenia and autism spectrum disorder, emphasizing the significance of calcium channels in neuronal migration and behavior regulation, thereby advancing our understanding of neurodevelopmental and psychiatric pathology.
