Publications by authors named "Shin-Yu Kung"
Article Synopsis
- Targeting microglia, a type of myeloid cell, is crucial for treating neuroinflammatory diseases like multiple sclerosis (MS), and researchers are exploring topoisomerase 1 (TOP1) inhibitors as potential therapies.
- Studies show that inhibiting TOP1 with drugs like camptothecin (CPT) and topotecan (TPT) reduces inflammation in microglia and helps alleviate neuroinflammation in living organisms.
- An innovative nanosystem, MyloGami, designed to specifically deliver TPT to myeloid cells, significantly decreases inflammation and slows the progression of MS, suggesting that TOP1 inhibition in these cells could be a viable treatment strategy for neuroinflammatory disorders.
Dendritic cells (DCs) devoid of the actin regulator Wiskott-Aldrich syndrome protein (WASp) show reduced directed migration and decreased formation of podosome adhesion structures. We examined DCs expressing a gain-of-function mutation in WASp, WASp L272P, identified in X-linked neutropenia patients. Analysis of WASp L272P DCs was compared to WASp-deficient DCs to examine how WASp activity influences DC migratory responses.
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