Publications by authors named "Shin-Ya Nakao"
Article Synopsis
- The study aims to find genetic factors that contribute to myopic macular neovascularization (mMNV) in people with severe myopia through a genome-wide association study (GWAS) meta-analysis.
- Researchers analyzed data from 2,783 highly myopic individuals, including 608 with mMNV and 2,175 controls, using advanced genetic analysis techniques.
- The study discovered a new genetic variant, rs56257842, associated with a lower risk of mMNV, and found that certain transcription factors interacted differently with this variant, suggesting it plays a significant role in the disease's development.
Pathological myopia (PM) is one of the leading causes of blindness, especially in Asia. To identify the genetic risk factors of PM, a two-stage genome-wide association study (GWAS) and replication analysis in East Asian populations is conducted. The analysis identified LILRB2 in 19q13.
View Article and Find Full Text PDFBackground/objectives: To investigate whether the corrective effect differs between upward and downward transpositions or between exotropia and esotropia in vertical transposition accompanied by horizontal rectus muscle recession-resection.
Subjects/methods: This prospective study investigated 41 patients with concomitant exotropia or esotropia with small-angle vertical deviation who underwent unilateral vertical transposition accompanied by horizontal rectus muscle recession-resection and were followed up for 1 year postoperatively. We analysed the vertical deviation corrective effect, defined as the corrective amount per displacement distance (°/tendon width [TW]).
Purpose: To evaluate the association between the duration of macular detachment (DMD) and visual prognosis in patients with macula-off rhegmatogenous retinal detachment (RD).
Design: Prospective observational cohort study.
Participants: This study analyzed 719 eyes with macula-off rhegmatogenous RD registered with the Japan-Retinal Detachment Registry created by the Japan Retina and Vitreous Society.
Article Synopsis
- - The study aimed to explore the genetic factors linked to age-related macular degeneration (AMD) specifically within a Japanese population by conducting a genome-wide association study (GWAS).
- - Researchers analyzed data from nearly 4,000 AMD patients and over 16,000 controls, identifying six genetic loci significantly associated with AMD, including two novel loci not previously linked to the disease.
- - The findings also revealed that these novel loci were associated with another eye condition, central serous chorioretinopathy (CSC), suggesting potential shared genetic mechanisms between AMD and CSC.
Purpose: To describe the distribution of ocular biometry and refraction in Japanese adults.
Design: Cross-sectional analysis of a prospective cohort study.
Participants: A total of 9850 individuals participated in the first follow-up of the Nagahama Prospective Cohort for Comprehensive Human Bioscience (the Nagahama Study) conducted between 2013 and 2016.