In this study, the transformation of sulfonamide antibiotics (SAs, 50 mg L(-1)) was investigated in systems consisting of a fungal laccase (6 IU) and six mediators (1mM). The results illustrate that the laccase had limited effect on the removal of sulfadimethoxine and sulfamonomethoxine. However, laccase oxidation with the mediators (LMS) led to significant declines of the SAs.
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